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ProteomicsOxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.
Ozone (O3) is a prevalent air pollutant that causes lung inflammation following exposure. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxidized cholesterol products (oxysterols), such as secosterol-A (secoA), which form covalent linkages prefere...
ORGANISM(S): Homo sapiens (Human) 
2021-06-21 | PXD019824 | Pride
Human Lc-msms Airway epithelium Lung inflammasome Alkynylated secosterol Click Protein modification Ozone Secosterols 
ProteomicsAlkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
These data correspond to "Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems," a paper from Codreanu, Liebler, et al, published at the journal _Molecular and Cellular Proteomics_ in 2013. Modifications also include: 4-hydroxynonenal (HNE) (UniMod #53), H(16) C(9) O(2), Mono...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-11-18 | MSV000078490 | MassIVE
ProteomicsAlkylation Damage by Lipid Electrophiles-- HNE-induced expression in RKO cells
4-hydroxynonenal (HNE) (UniMod 53) (+156.115030 Da on Cys, His, Lys) reduced 4-Hydroxynonenal (UniMod 335(+158.130680 Da on Cys, His, Lys) These data were additions to the set for the paper Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems by Codreanu et al, Mol. Cell. Pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-12-18 | MSV000078512 | MassIVE
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