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ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-27 | MSV000084240 | MassIVE
ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus musculus (Mouse) 
2014-09-25 | PXD000590 | Pride
Brain Postsynaptic density Hippocampus Data-independent acquisition 
ProteomicsUnbiased proteomic analysis of postsynaptic density fractions from Shank3 mutant mice reveals brain region specific changes highly relevant to autism spectrum disorder
Disruption of the human SHANK3 gene can cause several neuropsychiatric disease entities including Phelan-McDermid syndrome (PMS), autism spectrum disorders (ASDs) and intellectual disability (ID). Although a wide array of neurobiological studies strongly supports a major role for SHANK3 in organizin...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-08 | PXD005192 | Pride
Shank3 mutants Proteomics Hippocampus Striatum Postsynaptic density (psd) 
ProteomicsMutations in the postsynaptic signaling hub TNIK disrupts neuronal progenitor cells and immature neuronal function in human models of neurodevelopmental disease
Synaptic proteins, in particular those connected in large protein interaction networks at the postsynaptic site of glutamatergic neurons have been associated to a number of neurodevelopmental disorders. While their contribution to disease has been well documented in mature rodent synapses, their rol...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD035004 | Pride
Neurodevelopment Hipsc Signaling networks Disease Postsynaptic Signaling 
ProteomicsDevelopmental profile of core postsynaptic density protein complexes integrates signaling components of brain disorders
The postsynaptic density (PSD) contains a collection of scaffold proteins used for the assembly of synaptic signaling complexes and disruption of this signaling machinery might be implicated in a variety of brain disorders. However, it is not known how the core-scaffold machinery associates this col...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-22 | PXD006277 | Pride
Neuron Synaptic Psd 
ProteomicsDevelopmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation
The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered during development. However, the dynamics of synaptic protein composition across development have not...
ORGANISM(S): Mus musculus (Mouse) Callithrix jacchus 
2024-01-17 | PXD048549 | Pride
Brain postsynaptic density mouse primate 
ProteomicsComponents of lean-type and enriched-type PSD lattices
This project proposes a postsynaptic density (PSD) lattice model comprising a non-microtubule tubulin-based backbone structure and its associated proteins, including various PSD scaffold/adaptor proteins and other PSD proteins.
ORGANISM(S): Cellular Organisms 
2021-05-08 | PXD024712 | JPOST Repository
UnknownPostsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions.
Not available
S-EPMC6873588 | biostudies-literature
UnknownMultivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density.
Not available
S-EPMC10611757 | biostudies-literature
UnknownSite-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation.
Not available
S-EPMC8567388 | biostudies-literature
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