Sort   by:  
 Page size 
ProteomicsDevelopmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation
The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered during development. However, the dynamics of synaptic protein composition across development have not...
ORGANISM(S): Mus musculus (Mouse) Callithrix jacchus 
2024-01-17 | PXD048549 | Pride
Brain postsynaptic density mouse primate 
TranscriptomicsTranscription profiling time series of mouse hippocampal neuronal cultures during development
The expression of components of the synapse proteome was examined in genome-wide transcriptome profiles of differentiating hippocampus neurons (from 0.25 to 16 days in vitro) and microelectrode arrays was used to correlate the gene expression with electrical activity.
ORGANISM(S): Mus musculus 
2007-02-26 | E-MEXP-878 | biostudies-arrayexpress
ProteomicsZebrafish synaptic proteome - Evolution of complexity in the zebrafish synapse proteome
The proteome of human brain synapses is highly complex and mutated in over 130 diseases. This complexity arose from two whole genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases, however its synapse proteome is uncharacterised and whether the teleost-s...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Mus musculus (Mouse) 
2017-03-06 | PXD005630 | Pride
Synapse Zebrafish Evolution 
UnknownTrans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling.
Not available
S-EPMC2889310 | biostudies-literature
ProteomicsComplement C1q-dependent synapse elimination by astrocytes in a mouse model of Alzheimer's disease
Synapse loss and glial activation are hallmarks of Alzheimer's disease (AD). In Tau P301S transgenic mice, the complement pathway contributes to neuronal damage through microglial elimination of synapses. Here, we used unbiased proteomic profiling of postsynaptic density (PSD) fractions from Tau P30...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-03 | MSV000088313 | MassIVE
ProteomicsA cross-species proteomic map reveals neoteny of human synapse development - Macaque dataset
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins fr...
ORGANISM(S): Macaca Mulatta (ncbitaxon:9544) 
2023-05-08 | MSV000091889 | MassIVE
ProteomicsA cross-species proteomic map reveals neoteny of human synapse development - Mouse dataset
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins fr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-05-08 | MSV000091890 | MassIVE
ProteomicsA cross-species proteomic map reveals neoteny of human synapse development - Human V1 dataset
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins fr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-08 | MSV000091888 | MassIVE
ProteomicsCorrelation profiling of synaptic sub-fraction proteomes of the mouse brain hippocampus, cortex and cerebellum
Synaptic transmission forms the main mode of signaling and information integration in the nervous system. Here, we identified and quantified proteins from three brain regions and five biochemical synapse sub-fractions. We identified around 4500 proteins in total, of which about 2000 proteins each we...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-25 | PXD005634 | Pride
Post synaptic density Synapse Proteomics Correlation profiling 
ProteomicsA cross-species proteomic map reveals neoteny of human synapse development - Human main PFC dataset
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins fr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-08 | MSV000091887 | MassIVE
Sort   by:  
 Page size