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ProteomicsMacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes
Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic alterations in MDS patients strictly correlate with microenvironment dysfunctions, eventually affecting also the mesenchymal stromal cells (MSCs) compartment. Stromal cells are indeed epigenetically reprogramme...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039866 | Pride
Myelodysplastic syndromes Proteomics Macroh2a1.1 
ProteomicsProteomic analysis of Marinesco-Sjogren syndrome fibroblasts indicates pro-survival metabolic adaptation to SIL1 loss
Marinesco-Sjogren syndrome (MSS) is a rare multisystem pediatric disorder, caused by loss of function of the endoplasmic reticulum cochaperone SIL1 in about 60% of the patients. SIL1 acts as a nucleotide exchange factor for BiP, which plays a central role in secretory protein folding. SIL1-deficient...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029086 | Pride
Autophagosome Protein folding Bip Pathway analysis Fibroblast Unfolded protein response Neurodegenerative disease 
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