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Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high similarity within the evolutionary...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD015313 | Pride
Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high similarity within the evolutionary...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD015366 | Pride
In the context of intrabodies development for the synaptic protein PSD-95, we use proteomic approaches to evaluate the possible impact of one of our evolved PSD-95 binders on the endogenous PSD-95 function. More precisely, we compare the interactome of PSD-95 in presence or absence of the Xph20 bind...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-26 | PXD045002 | Pride
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