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TranscriptomicsTargeting c-MYC by antagonizing PP2A inhibitors in breast cancer
Inhibition of SET by siRNA or SET antagonist and CIP2A by siRNA can downregulate c-MYC and c-MYC target genes. Cells were treated with a SET antagonist (1μMOP449) for 12 hours, or siRNA for 48 hours.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-58008 | biostudies-arrayexpress
ProteomicsHeLa phosphoproteome regulated by PP2A related proteins
HeLa cells were treated with siRNAs of PP2A related proteins or with okadaic acid, in triplicates. Tryptic digests of extracted proteins were analyzed using a Q Exactive mass spectrometer, before and after TiO2 phosphopeptide enrichment. Data were searched with Mascot via Proteome Discoverer. For ph...
ORGANISM(S): Homo Sapiens (human) 
2020-02-19 | PXD016102 | JPOST Repository
TranscriptomicsThe yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4
The yeast PP2A-Cdc55 Serine/Threonine phosphatase regulates transcription under certain conditions. It is required for full activation of the environmental stress response mediated by the transcription factors Msn2 and Msn4. PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 a...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-07 | E-GEOD-38565 | biostudies-arrayexpress
ProteomicsA PP2A-Integrator complex fine-tunes transcription by opposing CDK9
In this study, we discovered that CDK9-mediated, RNAPII-driven transcription is functionally opposed by a protein phosphatase 2A (PP2A) complex that is recruited to transcription sites by the Integrator complex subunit INTS6. PP2A dynamically antagonises phosphorylation of key CDK9 substrates includ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025060 | Pride
Human Transcription Integrator Pp2a 
TranscriptomicsThe yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 2]
The yeast PP2A-Cdc55 Serine/Threonine phosphatase regulates transcription under certain conditions. It is required for full activation of the environmental stress response mediated by the transcription factors Msn2 and Msn4. PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 a...
ORGANISM(S): Saccharomyces cerevisiae W303 
2012-11-06 | E-GEOD-42033 | biostudies-arrayexpress
ProteomicsArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Arctigenin (ATG) is a major component of Fructus Arctii, which as a traditional herbal remedy reduced proteinuria in diabetic patients. However, whether ATG specifically provided renoprotection in DKD was not known. Here we report that ATG administration is sufficient to attenuate proteinuria and po...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD014976 | Pride
Actin cytoskeleton Podocytes Pp2a Drebrin-1 Arctigenin Diabetic kidney disease 
ProteomicsParallel PP2A activation and importin inhibition by sphingosine and related anti-neoplastic compounds
Sphingolipids enforce homeostatic cell growth in eukaryotes1,2. Phytosphingosine triggers an adaptive growth arrest in heat-stressed yeast while ceramide and its precursor/product sphingosine function as tumor suppressors in mammalian cells. Consistent with this, the constrained cyclic analogs of sp...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-14 | PXD036429 | Pride
Pp2a activation Importin inhibition Sphingosine Chemoproteomics 
GenomicsEffect of PP2A deficiency on gene expression in CD8+ T cells activation [bulkRNA-Seq]
Effect of PP2A deficiency on gene expression in CD8+ T cells activation [bulkRNA-Seq]
PRJNA1195599 | ENA
GenomicsEffect of PP2A deficiency on gene expression in CD8+ T cells activation [scRNA-Seq]
Effect of PP2A deficiency on gene expression in CD8+ T cells activation [scRNA-Seq]
PRJNA1195603 | ENA
GenomicsArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
PRJNA554786 | ENA
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