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ProteomicsThe PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii
Toxoplasma gondii is a significant pathogen affecting both humans and animals, with clinical symptoms primarily driven by the uncontrolled proliferation of tachyzoites. In this study, we reveal the essential role and functional plasticity of the PP2A-2 holoenzyme in orchestrating daughter cell emerg...
ORGANISM(S): Toxoplasma gondii 
2025-08-21 | PXD064226 | Pride
Toxoplasma gondii  pp2a-2 phosphatase  cytokinesis  cell division  daughter cell emergence  phosphoproteomics 
ProteomicsThe protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii
Phenotypic switching from tachyzoite to bradyzoite and vice versa is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite Toxoplasma gondii. Accumulation of cytoplasmic starch granules is a hallmark of the quiescent bradyzoite stage. The regulatory fact...
ORGANISM(S): Toxoplasma gondii 
2022-11-05 | PXD033120 | Pride
Pp2a holoenzyme Toxoplasma gondii Differentiation Dephosphorylation. Starch metabolism 
ProteomicsRegulation of PP2A-subfamily holoenzyme function by carboxyl-terminal methylation
The family of Phosphoprotein Phosphatases (PPPs) is responsible for most cellular serine and threonine dephosphorylation. PPPs achieve substrate specificity and selectivity by forming multimeric holoenzymes with catalytic, scaffolding, and regulatory subunits. Although there are only ten catalytic P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086183 | MassIVE
TranscriptomicsHost cell subversion by Toxoplasma GRA16, a HAUSP- and PP2A-interacting protein exported to the host cell nucleus
Toxoplasma gondii multiplies inside a parasitophorous vacuole in the host cell. Several parasite proteins have been described that hijack host signaling pathways, which mostly originate from the rhoptry organelles. We report here the identification and characterization of GRA16, the first dense gran...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-38779 | biostudies-arrayexpress
UnknownEffects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily.
Not available
S-EPMC8380034 | biostudies-literature
UnknownReduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B'δ holoenzyme.
Not available
S-EPMC7186168 | biostudies-literature
UnknownRegulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation.
Not available
S-EPMC8630191 | biostudies-literature
UnknownThe PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii.
Not available
S-EPMC12425318 | biostudies-literature
UnknownCoupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Not available
S-EPMC9398451 | biostudies-literature
UnknownSephin1 suppresses ER stress-induced cell death by inhibiting the formation of PP2A holoenzyme.
Not available
S-EPMC11840111 | biostudies-literature
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