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TranscriptomicsTargeting c-MYC by antagonizing PP2A inhibitors in breast cancer
Inhibition of SET by siRNA or SET antagonist and CIP2A by siRNA can downregulate c-MYC and c-MYC target genes. Cells were treated with a SET antagonist (1μMOP449) for 12 hours, or siRNA for 48 hours.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-58008 | biostudies-arrayexpress
ProteomicsHeLa phosphoproteome regulated by PP2A related proteins
HeLa cells were treated with siRNAs of PP2A related proteins or with okadaic acid, in triplicates. Tryptic digests of extracted proteins were analyzed using a Q Exactive mass spectrometer, before and after TiO2 phosphopeptide enrichment. Data were searched with Mascot via Proteome Discoverer. For ph...
ORGANISM(S): Homo Sapiens (human) 
2020-02-19 | PXD016102 | JPOST Repository
ProteomicsA PP2A-Integrator complex fine-tunes transcription by opposing CDK9
In this study, we discovered that CDK9-mediated, RNAPII-driven transcription is functionally opposed by a protein phosphatase 2A (PP2A) complex that is recruited to transcription sites by the Integrator complex subunit INTS6. PP2A dynamically antagonises phosphorylation of key CDK9 substrates includ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025060 | Pride
Human Transcription Integrator Pp2a 
ModelsMusante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions
Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Musante V, Li L, Kanyo ...
2024-09-02 | BIOMD0000000643 | BioModels
GenomicsTargeting the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma via PP2A Inhibition
Targeting the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma via PP2A Inhibition
PRJNA1414514 | ENA
GenomicsPP2A inhibition instructs spliceosome phosphorylation patterns to create splicing vulnerability in colon adenocarcinoma
PP2A inhibition instructs spliceosome phosphorylation patterns to create splicing vulnerability in colon adenocarcinoma
PRJNA991917 | ENA
ModelsMusante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3
Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3 This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. ...
2024-09-02 | BIOMD0000000644 | BioModels
GenomicsPP2A is essential for Th17 differentiaiton
PP2A is essential for Th17 differentiaiton
PRJNA490432 | ENA
ProteomicsPP2A inhibition instructs spliceosome phosphorylation patterns to create splicing vulnerability in colon adenocarcinoma
Protein phosphatase 2A (PP2A) is a promiscuous enzyme that acts on many aspects of cellular physiology. It remains unclear however, which of the cellular processes are most perturbed upon inhibition of PP2A and how such perturbations could be exploited therapeutically. Here, we report an unanticipat...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043658 | Pride
Pp2a inhibition Lb-100 Phosphorylation Colon adenocarcinoma Alternative splicing 
ModelsMusante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3 and dominant negative effect
Musante2017 - Switching behaviour of PP2A inhibition by ARPP-16 - mutual inhibitions and PKA inhibits MAST3 and dominant negative effect This model is described in the article: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein pho...
2024-09-02 | BIOMD0000000645 | BioModels
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