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ProteomicsInfluence of mutations in PPE38 on the secretome composition of M. tuberculosis
What is the influence of mutations in PPE38 on the secretome composition of M. tuberculosis? Certain clinical isolates of M. tuberculosis belonging to the Beijing lineage have mutations in ppe38 and this leads to a loss of secretion of the PE_PGRS substrates and hypervirulence in a mouse model of M....
ORGANISM(S): Mycobacterium tuberculosis 
2017-10-11 | PXD003842 | Pride
Mycobacterium tuberculosis Single-shot Label-free Ppe38 Secretome 
UnknownPPE38 Protein of Mycobacterium tuberculosis Inhibits Macrophage MHC Class I Expression and Dampens CD8+ T Cell Responses.
Not available
S-EPMC5346565 | biostudies-literature
UnknownPPE38 of Mycobacterium marinum triggers the cross-talk of multiple pathways involved in the host response, as revealed by subcellular quantitative proteomics.
Not available
S-EPMC3646403 | biostudies-literature
UnknownPPE38-Secretion-Dependent Proteins of <i>M. tuberculosis</i> Alter NF-kB Signalling and Inflammatory Responses in Macrophages.
Not available
S-EPMC8284050 | biostudies-literature
Genomicsppe37 mutations in Mycobacterium tuberculosis
Mutations in ppe38 block PE_PGRS secretion and cause hypervirulence in Mycobacterium tuberculosis
PRJEB14401 | ENA
ProteomicsMycobacterium tuberculosis whole cell lysates
Proteomics on whole cell lysates from Mycobacterium tuberculosis CDC1551, a ppe38-ppe71 deletion mutant and a complemented strain grown in modified sautons medium till mid logarithmic phase
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2021-06-15 | PXD020814 | Pride
Mycobacterium tuberculosis Whole cell lysate Lc-ms/ms 
ProteomicsPulse-chase SILAC of Mycobacterium tuberculosis infected THP-1 macrophages
Pulse chase SILAC was used to identify protein turnover within human macrophages infected with mycobacterium tuberculosis CDC1551, a ppe38-71 mutant strain, a complemented strain and an uninfected control.
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD021166 | Pride
Lc-ms/ms Tuberculosis Silac Macrophages 
ProteomicsMycobacterium tuberculosis tween supernatants
Supernatants of M. tuberculosis CDC1551, a ppe38-ppe71 knock out mutant and a complemented strain containing tween was used for mass spectrometry and proteomics study to identify the differential regulation of proteins between these strains.
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2021-06-15 | PXD020813 | Pride
Mycobacterium tuberculosis Lc-ms/ms 
ProteomicsMycobacterium tuberculosis tween supernatants
Tween free supernatants of M. tuberculosis CDC1551, a ppe38-ppe71 knock out mutant and a complemented strain containing tween was used for mass spectrometry and proteomics study to identify the differential regulation of proteins between these strains.
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2021-06-15 | PXD021168 | Pride
Mycobacterium tuberculosis Lc-ms/ms 
ProteomicsMycobacterium tuberculosis tween supernatants
Whole cell lysates of THP-1 macrophages infected with of M. tuberculosis CDC1551, a ppe38-ppe71 knock out mutant and a complemented strain was performed at 4h and 18h post infection to find the differentially regulated proteins.
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD021167 | Pride
Mycobacterium tuberculosis Lc-ms/ms 
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