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UnknownPpp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.
Not available
S-EPMC8177767 | biostudies-literature
ProteomicsEnergy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
In this project, SILAC-based quantitative proteomics approach was applied for phosphoproteomics analysis. The light samples were treated with ddH2O as control group, and the medium samples labeled by 2D2 of lysine (K4) and 13C6 of arginine (R6) were treated with 2DG, while the heavy samples labeled ...
ORGANISM(S): Homo Sapiens 
2022-11-08 | PXD038034 |
UnknownDeficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
Not available
S-EPMC9288536 | biostudies-literature
UnknownPPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
Not available
S-EPMC8068315 | biostudies-literature
GenomicsmiR-208a-3p targets PPP6C to regulate the progression of Radiation-induced lung injury
miR-208a-3p targets PPP6C to regulate the progression of Radiation-induced lung injury
PRJNA1141924 | ENA
GenomicsmiR-208a-3p targets PPP6C to regulate the progression of Radiation-induced lung injury
Aims: Radiation-induced lung injury (RILI) is a common complication after radiotherapy for clinical thoracic tumors, and increasing evidence suggests that miRNAs have potential value as biomarkers for early warning. However, the potential mechanism is still obscure. Here, we evaluated miRNAs-depende...
ORGANISM(S): Mus musculus 
2025-07-01 | GSE273437 | GEO
UnknownDephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Not available
S-EPMC7381519 | biostudies-literature
UnknownPPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity.
Not available
S-EPMC8976846 | biostudies-literature
UnknownMiR-20a-5p functions as a potent tumor suppressor by targeting PPP6C in acute myeloid leukemia.
Not available
S-EPMC8480815 | biostudies-literature
ProteomicsSpecific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis
Protein phosphatase 6 (PP6) is a member of the PP2A-like subfamily, which plays significant roles in numerous fundamental biological activities. We found that PPP6C plays important roles in male germ cells recently. Spermatogenesis is supported by the Sertoli cells in seminiferous epithelium. In thi...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028051 | Pride
Ppp6c Phosphoproteome Sertoli cells Spermatogenesis Β-catenin 
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