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ProteomicsMicrocystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells
Microcystin-LR (MCLR) exposure has been associated with development of hepatocellular carcinoma (HCC). Many of the carcinogenic mechanisms for MCLR have been attributed to the induction of cell survival and proliferation through altered protein phosphorylation pathways by inhibition of protein phosp...
ORGANISM(S): Homo sapiens (Human) 
2025-02-05 | PXD054405 | Pride
Protein phosphatase Mitogen-activated protein kinase Microcystin-lr Protein phosphorylation Phosphoproteomics Heparg cells 
ProteomicsQuantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling
Rats are extensively used preclinical models for assessing drug pharmacokinetics (PK) and tissue distribution; however, a successful translation of the rat data requires information on the differences in drug metabolism and transport mechanisms between rats and humans. To partly fill this knowledge ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-02-05 | PXD039271 | Pride
Pbpk modeling Quantitative proteomics Drug metabolism Total protein approach Digoxin Drug transport Interspecies differences 
ProteomicsFunctional effects of CYP3A-CYP2E1 interactions and their role in activation of CYP3A enzymes by chronic alcohol exposure
Aiming to examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of two CYP3A-specific substrates, 7-benzyloxyquinoline (7-BQ) and ivermectin, in 23 preparations of human liver microsomes (HLM) obtained from donors with documented al...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD079247 | Pride
Cytochrome p450  cyp2e1  cyp3a4  cyp3a5  nadph-cytochrome p450 reductase  pro-tein-protein interactions  7-benzyloxyquinoline  ivermectin  human liver microsomes  alcohol consumption  alcohol-drug interactions  cross-linking mass spectrometry 
ProteomicsThe ontogeny and inter-individual variability of drug- metabolizing enzymes and transporters in human liver.
Drug dosing for children is frequently suboptimal when relying on the traditional approach of normalizing doses based on body weight or surface area. Thus, the ontogeny profiling of drug-metabolizing enzymes (DMEs) is important to help develop physiologically-based pharmacokinetic (PBPK) models for ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-05 | PXD060483 | Pride
Ontogeny Human liver Hydrolytic drug-metabolizing enzymes 
UnknownOptimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics.
Not available
S-EPMC4070263 | biostudies-literature
UnknownThe Promises of Quantitative Proteomics in Precision Medicine.
Not available
S-EPMC5313344 | biostudies-literature
UnknownHarnessing Solute Carrier Transporters for Precision Oncology.
Not available
S-EPMC5570559 | biostudies-literature
UnknownMajor glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.
Not available
S-EPMC7075494 | biostudies-literature
UnknownOptimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Not available
S-EPMC7413827 | biostudies-literature
UnknownAge-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Not available
S-EPMC5563927 | biostudies-literature
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