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ProteomicsHypolipidemic effects of beetroot juice in SHR-CRP and HHTg rat models of metabolic syndrome: Analysis of hepatic proteome.
Recently, red beetroot has attracted attention as a health promoting functional food. Studies showed that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism, however, mechanisms underlying these beneficial effects of beetroot are not fully und...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD039605 | Pride
Mtor signaling Spontaneously hypertensive rat Lipids Glycerophospholipid metabolism Beetroot Hereditary hypertriglyceridemic rat 
ProteomicsSpontaneous nonsense mutation in Tuft1 (tuftelin 1) gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat
A new spontaneous mutation, abnormal hair appearance in the rat, has been identified as a non-functional Tuft1 (tuftelin 1) gene. The pleiotropic effects of this mutation regulate glucose and lipid metabolism. Analysis of the liver proteome revealed possible molecular mechanisms for the metabolic ef...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-03-12 | PXD045880 | Pride
Hepatic proteome  lipid and glucose metabolism  rat  spontaneous nonsense mutation  tuft1 (tuftelin 1) gene 
TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsFumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats
Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate (DMF), exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid este...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-MTAB-2406 | biostudies-arrayexpress
TranscriptomicsDownregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, a quantitative trait locus (QTL) influencing blood pressure, left ventricular mass and heart...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3831 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Sprague Dawley Rat Skin Treated with Aldosterone or Vehicle on High-Salt Diet for 2 or 14 Days
This study investigates the molecular mechanisms underlying salt-sensitive hypertension in a model of primary aldosteronism using RNA-Seq analysis of Sprague Dawley rat skin. Unilaterally nephrectomized rats were treated with aldosterone or vehicle and fed a high-salt or low-salt diet. Tissue electr...
ORGANISM(S): Rattus norvegicus 
2026-01-20 | E-MTAB-14749 | biostudies-arrayexpress
GenomicsNatural variation of histone modification and its impact on gene expression in rat
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. To begin to understand the impact of natural variation on histone methylation levels we generated and quantified large-scale ...
ORGANISM(S): Rattus norvegicus 
2012-05-30 | E-MTAB-1102 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of kidney from rats of SHR/Ola, BN and SHR-18 strains after being provided with drinking water with 1% or 0% sodium chloride
Four male SHR/Ola, BN and SHR-18 rats were fed a normal diet and sacrificed at 9 weeks of age. Four male SHR/Ola and SHR-18 rats at 8 weeks of age were fed 1% NaCl for one week and then sacrificed. Kidneys were removed and frozen in liquid nitrogen for all 20 animals. Total RNA was isolated, labelle...
ORGANISM(S): Rattus norvegicus 
2008-04-01 | E-MIMR-1122 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains
Gene expression profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains.
ORGANISM(S): Rattus norvegicus 
2010-11-18 | E-AFMX-7 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse heart implicatesosteoglycin (Ogn) in the regulation of left ventricular mass
Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript (QTT) analyses of the cardiac transc...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-10161 | biostudies-arrayexpress
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