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TranscriptomicsLack of Toll-like Receptor Signaling Improves Host Defense in Severe Septic Peritonitis in Severe Septic Peritonitis
TLRs are considered important for innate immune responses that combat bacterial infections. Here, the role of TLRs in severe septic peritonitis using the colon ascendens stent peritonitis (CASP) model was examined. We demonstrate that mice deficient for MyD88 and TRIF had markedly reduced bacterial ...
ORGANISM(S): Mus musculus 
2011-06-27 | E-GEOD-24327 | biostudies-arrayexpress
TranscriptomicsDissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
NIH-3T3 cells were pretreated for 15 min with either DMSO (mock) or cycloheximide followed by addition of either mock, 100 U/ml IFNalpha or 100 U/ml IFNgamma for 1h. During the last 30 min, 500 µM 4-thiouridine was added to cell culture medium. Total cellular RNA was isolated using Trizol reagent an...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-30457 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human CD1c+ CD19- blood dendritic cells [human data]
In this study gene expression of CD1c+ CD19- blood dendritic cells from healthy subjects were investigated. Keywords: expression profiling by array Blood DCs (CD1c+ CD19-) were isolated from venous heparinized blood of three apparently healthy human volunteers using the CD1c+ (BDCA-1) dendritic cell...
ORGANISM(S): Homo sapiens 
2011-12-17 | E-GEOD-34515 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Ewing's sarcoma derived exosomes
Exosomes are small RNA and protein containing vesicles that can mediate hetero- and homotypic intercellular communication between normal and malignant cells. Especially, tumor-derived exosomes are believed to mediate reprogramming of the tumor-associated stroma to favor tumor growth and metastasis. ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42282 | biostudies-arrayexpress
TranscriptomicsEwing sarcoma compared to a normal body map
Primary pediatric Ewing sarcoma (ES), one uncharacterized sarcoma as well as primary and well established ES cell lines were compared to probes of different normal tissues 8 Ewing sarcoma patient samples (MuET-x), 3 primary ES cell lines (SB-KMS-y), 3 well established ES cell lines (A673, SK-N-MC, R...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-45544 | biostudies-arrayexpress
TranscriptomicsExpression profile of Ewing sarcoma and osteosarcoma
The expression profile of primary pediatric Ewing sarcoma (ES) and osteosarcoma (OS) were analyzed. 8 Ewing sarcoma patient samples (TUM-ES0XXX) and 10 osteosarcoma patient samples (TUM-OS0XXX) were analyzed.
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-73166 | biostudies-arrayexpress
TranscriptomicsMondoA is highly expressed in acute lymphoblastic leukemia and modulates metabolism, differentiation and survival
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted treatment of childhood ALL, we performed a comprehensive transcriptome analysis yielding a set of genes specifically overexpressed in ALL. Among them we identified MondoA - a transcripti...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33967 | biostudies-arrayexpress
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