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TranscriptomicsTranscriptome profiling of mouse embryonic fibroblasts upon contact inhibition
Chromatin modifying activities for construction of appropriate epigenetic landscapes by polycomb repressive complex 2 (PRC2) play an essential role in development and tumorigenesis. However, the spatiotemporal mechanisms by which PRC2 achieves diverse epigenomes for specific tissue or cellular conte...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-63535 | biostudies-arrayexpress
GenomicsFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterize AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, incl...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83082 | biostudies-arrayexpress
GenomicsMultiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma
PRJNA487522 | ENA
TranscriptomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [iTC-seq_drugs]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58018 | biostudies-arrayexpress
GenomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [ChIP-seq_drugs]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58019 | biostudies-arrayexpress
ProteomicsPRC2 loss impairs small cell lung cancer tumorigenesis and enhances sensitivity to G9a/GLP inhibition
Effective targeted therapies remain a major challenge for patients with small cell lung cancer (SCLC). Targeting the epigenome of SCLC to address immune evasion and chemoresistance offers a promising strategy to improve treatment outcomes. In this study, we investigate the role of Polycomb repressiv...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD067850 | Pride
Small cell lung cancer Combination therapy Preclinical models Eed Ezh2 Targeted therapy 
GenomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [ChIP-seq_Input]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58022 | biostudies-arrayexpress
ProteomicsTwo distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the PRC2 core associates with distinct ancillary subunits such as...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-07 | PXD014290 | Pride
Chromatin Prc2 Embryonic stem cells Polycomb 
ProteomicsTwo distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the PRC2 core associates with distinct ancillary subunits such as...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-22 | PXD020684 | Pride
Chromatin Prc2 Embryonic stem cells Polycomb 
TranscriptomicsGene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide [RNA-seq_differentiation]
Polycomb group (PcG) proteins are required for normal differentiation and development, and their activity is found deregulated in cancer. PcG proteins are involved in gene silencing, however, whether they initiate or maintain transcriptional repression is a subject of debate. Here, we show that knoc...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-58017 | biostudies-arrayexpress
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