Sort   by:  
 Page size 
TranscriptomicsPolycomb protein EED is required for selective silencing of pluripotency genes upon ESC differentiation
Eed (embryonic ectoderm development) is a core component of the Polycomb Repressive Complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 (H3K27me3) can act as a signal for PRC1 recruitment in the process of gene silencing and chromatin condensation. P...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-49305 | biostudies-arrayexpress
GenomicsBulk RNA-seq of Colonic Epithelia from EED and EED/Satb2 Double Knockout Mice
Bulk RNA-seq of Colonic Epithelia from EED and EED/Satb2 Double Knockout Mice
PRJNA746272 | ENA
GenomicsEED inhibitor impedes dendritic cell inflammatory functions
EED inhibitor impedes dendritic cell inflammatory functions
PRJNA1154627 | ENA
ProteomicsIP-MS of Polycomb proteins in quiescent vs. cycling cells
IP-MS was used to determine the (differential) interactome of several Polycomp group proteins (EED, EZH1, EZH2, RING1B) in quiescent vs. cycling human fibroblasts. This data complements additional experiments performed in the same study.
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD058533 | Pride
Ip-ms Polycomb Eed Quiescent Ezh2 Cycling Ezh1 Ring1b 
GenomicsMouse Embryo Sox1 cre-dependent knockout of EED
Mouse Embryo Sox1 cre-dependent knockout of EED
PRJNA436234 | ENA
TranscriptomicsExpression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML
We evaluated gene expression changes in murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of homozygous conditional alleles for Ezh2 or Eed, both of which are components of the Polycomb...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34959 | biostudies-arrayexpress
UnknownMaintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.
Not available
S-EPMC4949429 | biostudies-literature
GenomicsThe Central Role of EED in the Orchestration of Polycomb Group Complexes
Polycomb Repressive Complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency, and neoplastic progression1-3. Here we show that the Polycomb group protein EED, a core component of PRC2, physically intera...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-42566 | biostudies-arrayexpress
GenomicsEpigenomic profiling of Non-small-cell Lung Cancer (NSCLC) cells with or without Eed
Polycomb repressive complexes (PRC) are frequently implicated in human cancer acting either as oncogenes or tumor suppressors. Here we show that PRC2 is a critical regulator of Kras-driven non-small-cell lung cancer (NSCLC) progression. Modulation of PRC2 by either Ezh2 overexpression or Eed deletio...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-61190 | biostudies-arrayexpress
UnknownPolycomb Repressive Complex 2 Modulation through the Development of EZH2-EED Interaction Inhibitors and EED Binders.
Not available
S-EPMC8404197 | biostudies-literature
Sort   by:  
 Page size