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GenomicsPolycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, Enhancer of Zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine-27 of histone H3 (...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-25549 | biostudies-arrayexpress
ProteomicsProtein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression
The MS data of Protein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression Protein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression
ORGANISM(S): Homo Sapiens 
2019-12-11 | PXD016712 |
TranscriptomicsEZH1 and EZH2 Co-Govern Histone H3-K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair
Polycomb protein group (PcG)-dependent trimethylation on H3-K27(H3K27me3) regulates identity of embryonic stem cells (SCs). How H3K27me3 governs adult SCs and tissue development is unclear. Here, we conditionally target H3-K27-methyltransferases Ezh2 and Ezh1 to address their roles in mouse skin hom...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-26616 | biostudies-arrayexpress
GenomicsLoss of EZH2 results in enhanced recruitment of EZH1, Pol II and Stat5 and precocious mammary gland development
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factor STAT5. As pregnancy progresses mammary signature genes are activated in a defined temporal order, which coincides with the recruitment of STAT5 to respective regulatory ...
ORGANISM(S): Mus musculus 
2015-01-27 | E-GEOD-65284 | biostudies-arrayexpress
ProteomicsEZH1 Orchestrates Rhythmicity of Circadian Gene Expression Acting on Transcription Machinery Integrity
Circadian rhythmicity of gene expression is a conserved feature of cell physiology. This involves fine tuning between transcriptional and post-transcriptional molecular mechanisms, strongly dependent on the metabolic state of the cell, which guarantees adaptive plasticity of tissue-specific genetic ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-11 | PXD035453 | Pride
Circadian rhythm Transcription Ezh1 
TranscriptomicsDisruption of H3K27me3 through loss of EZH1 and EZH2 accelerates progression of hepatosteatosis to fatal liver fibrosis
Although epigenetic mechanisms, such as specific histone modifications, control common and cell-specific genetic programs, a role for histone modifying enzymes in liver metabolism and disease has not been investigated. This report demonstrates that the combined loss of the histone methyltransferases...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53627 | biostudies-arrayexpress
GenomicsChIP-seq analysis of PRC2 core subunits in primary human erythroid progenitor cells
Polycomb Repressive Complex 2 (PRC2) plays crucial roles in transcriptional regulation and stem cell development. However, the context-specific functions associated with alternative subunits remain largely unexplored. Here we show that the related enzymatic subunits EZH1 and EZH2 undergo an expressi...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-59087 | biostudies-arrayexpress
TranscriptomicsRNA-seq transcriptional profiling in primary human erythroid progenitor cells upon shRNA-mediated knockdown of PRC2 core subunits
Polycomb Repressive Complex 2 (PRC2) plays crucial roles in transcriptional regulation and stem cell development. However, the context-specific functions associated with alternative subunits remain largely unexplored. Here we show that the related enzymatic subunits EZH1 and EZH2 undergo an expressi...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-59089 | biostudies-arrayexpress
ProteomicsIP-MS of Polycomb proteins in quiescent vs. cycling cells
IP-MS was used to determine the (differential) interactome of several Polycomp group proteins (EED, EZH1, EZH2, RING1B) in quiescent vs. cycling human fibroblasts. This data complements additional experiments performed in the same study.
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD058533 | Pride
Ip-ms Polycomb Eed Quiescent Ezh2 Cycling Ezh1 Ring1b 
TranscriptomicsExpression data from LSK cells from mice with knock-out of Ezh1 versus LSK control
Ezh1 is a protein member of PRC2. Ezh1 has been described as a functional repressor gene, such as its homologous Ezh2. We are investigating the role of Ezh1 in hematopoietic stem cells, aging, self-renewal and differentiation. We used microarrays to detail the global program of gene expression in LS...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-36288 | biostudies-arrayexpress
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