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MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
TranscriptomicsGene expression in mouse pre-B cells transduced with Ikaros.
Ikaros family DNA binding proteins are critical regulators of B cell development. To identify Ikaros-regulated genes in pre-B cells we performed gene expression studies at enhanced temporal resolution. We used retroviral gene transfer to express Ikaros proteins in the pre-B cell line B3. Total RNA f...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-38110 | biostudies-arrayexpress
GenomicsGenome-wide identification of Ikaros binding sites in primary pre-B cells
Ikaros DNA binding proteins are important regulators of haematopoiesis and genetic deletion of Ikaros results in severe developmental disturbances, including delayed thymocyte differentiation and an early and complete block in B cell development. Although Ikaros ChIP-seq data are available for mouse...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-42462 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse primary pre-B cells transduced with Ikaros
Ikaros family DNA binding proteins are critical regulators of B cell development. To identify Ikaros-regulated genes in primary pre-B cells we performed gene expression microarrays. We used retroviral gene transfer to express Ikaros proteins. Total RNA from 3 biological replicates of primary pre-B c...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-42551 | biostudies-arrayexpress
GenomicsGenome-wide identification of Ikaros binding sites in pre-B cells
Ikaros DNA binding proteins are important regulators of haematopoiesis and genetic deletion of Ikaros results in severe developmental disturbances, including delayed thymocyte differentiation and an early and complete block in B cell development. Although Ikaros ChIP-seq data are available for mouse...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-38169 | biostudies-arrayexpress
TranscriptomicsRole and function of Bach2 in BCR-ABL1 driven pre-B ALL
In order to investigate the function of Bach2 in pre-B ALL, we isolated bone marrow cells from wildtype and Bach2 knockout mice of C57Bl6 background and transformed them with BCR-ABL1. We compared the gene expression profiles of Bach2 wildtype and knockout pre-B ALL cells, both with and without ima...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-30883 | biostudies-arrayexpress
TranscriptomicsIkaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia
Deletion of the Ikaros DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias (B-ALL).  Here, we show that conditional inactivation of the Ikaros DNA binding domain i...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53401 | biostudies-arrayexpress
GenomicsIkaros target genes in the mouse pre-B cell line B3
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-38200 | biostudies-arrayexpress
TranscriptomicsEffect of Bach2 overexpression in BCL6+/+ and -/- BCR-ABL1 transformed pre-B cells
The aim was to investigate how BCL6 genotype affects Bach2 dependent gene expression changes. We compared gene expression profiles of BCL6+/+ and BCL6-/- BCR-ABL1 transformed pre-B cells after inducible overexpression of Bach2.
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-41042 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Abl pre-B cell lines with conditional deletion of dicer
Abelson virus (v-Abl)-transformed pre-B cell lines from BM of dcrfl/fl; R26R-yfp (4470; 4475) and dcrfl/+; R26R-yfp mice (4483) are treated with a transducible Cre protein (Tat-Cre) to induce deletion of the dicer-1 gene in vitro. Cre activity is conveniently monitored by concomitant expression of Y...
ORGANISM(S): Mus musculus 
2008-03-08 | E-MEXP-1455 | biostudies-arrayexpress
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