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TranscriptomicsTranscription profiling of human prefrontal cortex during postnatal development
Fresh frozen post mortem prefrontal cortex tissue (Brodman area 46) was obtained from 44 individuals varying in age from 0 to 49 years. RNA was extracted from these samples and hybridized to HG133plus2.0 GeneChips. The data was used to examine patterns of gene expression over the course of human pos...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-13564 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse prefrontal cortex of C57Bl/6J mice at Zeitgeber Time (ZT) 3, 9, 15, and 21.
Background: The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by the sleep-wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provi...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9471 | biostudies-arrayexpress
GenomicsDevelopmental Regulation and Individual Differences of Neuronal Epigenomes in the Prefrontal Cortex
We report global distribution of trimethylated Histone H3 Lysine 4 (H3K4me3) in human prefrontal cortex neurons at different ages Neuronal nuclei from human prefrontal cortex were isolated by FACS. Regions marked by H3K4me3 were identified by chromatin immunoprecipiation followed by deep sequencing.
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-21172 | biostudies-arrayexpress
TranscriptomicsWhole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
Whole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
ORGANISM(S): Homo sapiens 
2012-09-19 | E-MTAB-812 | biostudies-arrayexpress
TranscriptomicsProfiling Transcriptomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders
Analysis of transcriptiomic alternations related with alcohol use disorders (AUDs). The hypothesis is that chronic alcohol consumption might alter genome-wide gene expression patterns. The results suggest that differential gene expression in the prefrontal cortex is implicated in neuroadaptations to...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49376 | biostudies-arrayexpress
TranscriptomicsTemporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex
In order to gain a global molecular perspective on how the human genome gives rise to the brain, we explore the temporal dynamics and genetic control of transcription in human dorsolateral prefrontal cortex in an extensive series of brain tissue from fetal development through aging. We discover a wa...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-30272 | biostudies-arrayexpress
TranscriptomicsProfiling Methylomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders
Analysis of methylomic alternations related with alcohol use disorders (AUD). The hypothesis is that chronic alcohol consumption might alter genome-wide DNA methylation patterns. The results suggest that differential DNA methylation might be invovled in neuradaptations to alcohol. Genomic DNA was ex...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49393 | biostudies-arrayexpress
ProteomicsSchizophrenia brain proteomic analysis
The purpose of the study was to identify altered molecular networks in the prefrontal cortex of schizophrenia patients by comparing protein expression levels in autopsied brains of patients (n=10) and controls (n=10), using aquantitative proteomics.
ORGANISM(S): Homo Sapiens (human) 
2018-01-01 | PXD008227 | JPOST Repository
GenomicsH3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples
Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion in the number of CAG repeats in the coding region of exon 1 of the Huntingtin (HTT) gene. One of the most widely studied chromatin modifications is trimethylated lysine 4 of histone 3 (H3K4me3). ...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-68952 | biostudies-arrayexpress
TranscriptomicsAge-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
The molecular basis of complex neuropsychiatric disorders most likely involves many genes. In recent years, specific genetic variations influencing risk for schizophrenia and other neuropsychiatric disorders have been reported. We have used custom DNA microarrays and qPCR to investigate the expressi...
ORGANISM(S): Homo sapiens 
2008-05-23 | E-GEOD-11546 | biostudies-arrayexpress
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