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TranscriptomicsTranscription profiling of rat liver samples treated with pregnenolone 16alpha-carbonitrile
Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat ...
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-4959 | biostudies-arrayexpress
ProteomicsClick-enabled analogues reveal pregnenolone interactomes in cancer and immune cells
Click-enabled analogues reveal pregnenolone interactomes in cancer and immune cells. TMT-6 experiment of tryptic, carbamidomethylated peptides of mouse CD8+ T-cells after protein pull-down on pregnenolone beads.
ORGANISM(S): Mus musculus (Mouse) 
2021-04-26 | PXD025574 | Pride
Pregnenolone pull-down cd8+ t-cells 
ProteomicsRat liver treated by PCN
The combination analyses of transcriptomics, proteomics, phosphoproteomics, and metabolomics in rat liver after repeated oral doses of PXR agonist, PCN, for 7 days were conducted to understand the roles for PXR on non-genotoxic signaling and energy homeostasis. mRNA and proteins in homogenate supern...
ORGANISM(S): Rattus Rattus (black Rat) 
2018-01-01 | PXD006305 | JPOST Repository
GenomicsRegulation of T cell gene expression and function by the steroid hormone precursor Pregnenolone
Regulation of T cell gene expression and function by the steroid hormone precursor Pregnenolone
PRJNA937234 | ENA
TranscriptomicsRegulation of T cell gene expression and function by the steroid hormone precursor Pregnenolone
We report the transcriptional changes in primary T cells expanded from peripheral blood mononuclear cells (PBMCs) upon treatemnt with the steroid precursor, pregnenolone.
ORGANISM(S): Homo sapiens 
2024-03-20 | GSE225725 | GEO
UnknownMitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells.
Not available
S-EPMC10413356 | biostudies-literature
TranscriptomicsGene expression analysis in rat liver after exposure to pregnenolone-16α-carbonitrile
RCCHanTM:WIST male rats were administered for 7 days by oral gavage with vehicle (corn oil) or 100 mg/kg/day of pregnenolone-16α-carbonitrile(PCN). We used microarrays to evaluate gene expression profiling in rat liver at the early phase of treatment with PCN.
ORGANISM(S): Rattus norvegicus 
2018-10-10 | GSE95475 | GEO
UnknownPregnenolone blocks cannabinoid-induced acute psychotic-like states in mice.
Not available
S-EPMC5447368 | biostudies-literature
UnknownClock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis.
Not available
S-EPMC7589815 | biostudies-literature
UnknownBK channel-forming slo1 proteins mediate the brain artery constriction evoked by the neurosteroid pregnenolone.
Not available
S-EPMC8274572 | biostudies-literature
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