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MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
MetabolomicsBiomonitoring of mycotoxins and exposomics-informed profiling in extreme preterm infants from the NeoVIP cohort

Extremely premature infants are a highly vulnerable patient group that might be exposed to a vast number of dietary and environmental contaminants, which may impact their health trajectories. This study assessed xenobiotic exposures in 26 extremely premature infants, with a special focus on dieta...

2026-06-23 | MTBLS14832 | MetaboLights
TranscriptomicsGenome-Wide Expression Profiles in Very Low Birth Weight Infants With Neonatal Sepsis
Bacterial sepsis is associated with high morbidity and mortality in preterm infants. However, diagnosis of sepsis and identification of the causative agent remains challenging. Our aim was to determine genome-wide expression profiles of very low birth weight (VLBW) infants with and without bacterial...
ORGANISM(S): Homo sapiens 
2016-05-29 | E-MTAB-4785 | biostudies-arrayexpress
ProteomicsComposition and origin of lung fluid proteome in premature infants and relationship to respiratory outcome
We performed global proteomics of premature infant tracheal aspirate (TA) and plasma to determine the composition and source of lung fluid proteins and to identify potential biomarkers of respiratory outcome
ORGANISM(S): Homo sapiens (Human) 
2020-11-23 | PXD021966 | Pride
Tracheal aspirate Plasma Lung disease Premature infants 
ProteomicsMetaproteome of preterm infant gut microbiome
91 preterm infant gut metaproteomes measured in technical duplicate using an eleven salt pulse 2D-LC-MS/MS method. Samples represent 17 preterm infants over the first several weeks of life, of which 6 preterm infants eventually developed necrotizing enterocolitis.
ORGANISM(S): Microbiome 
MSV000086096 | MassIVE
TranscriptomicsRNA-seq of peripheral whole blood from ten healthy preterm infants and ten preterm infants with bronchopulmonary dysplasia
We procured peripheral whole blood from ten healthy preterm infants and ten preterm infants with bronchopulmonary dysplasia
ORGANISM(S): Homo sapiens 
2024-10-27 | E-MTAB-14506 | biostudies-arrayexpress
ProteomicsNetwork Analysis Reveals Age- and Virus-Specific Circuits in Nasal Epithelial Cells of Extremely Premature Infants
Viral respiratory infections significantly affect young children, particularly extremely premature infants, resulting in high hospitalization rates and increased health-care burdens. Despite posing substantial health risks, airway immune responses in early life remain largely unexplored. Nasal epith...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD042209 | Pride
Nasal epithelial cells Premature infants Virus-specific pathways 
GenomicsT cell receptor repertoire in premature infants
T cell receptor repertoire in premature infants
PRJNA797011 | ENA
TranscriptomicsSingle-cell RNA sequencing of PBMCs from five healthy (HC) preterm infants and ten preterm infants with bronchopulmonary dysplasia(BPD)
We procured PBMCs whole blood from five HC preterm infants and five preterm infants with BPD. PBMCs were extracted using a density gradient centrifugation method. Initially, 10ml of peripheral blood was mixed with an equal volume of physiological saline, then carefully layered onto Ficoll solution (...
ORGANISM(S): Homo sapiens 
2024-10-20 | E-MTAB-14507 | biostudies-arrayexpress
GenomicsMacrophage response in preterm infants compared to term infants
Preterm infants are highly susceptible to sustained lung inflammation, which may be triggered by exposure to multiple environmental cues such as supplemental oxygen (O2) and infections. The underlying mechanisms are still poorly understood. The hypothesis of this study is that dysregulated macrophag...
EGAS00001004974 | EGA
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