Premature termination codon

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[1]University of Iowa, Carver College of Medicine, Iowa City, Iowa, 52242, USA [2]University of Rochester, Rochester, NY, 14642 (1)

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Misincorporations at Artificially Constructed Termination Stop Codons in the Presence of the Amino Glycoside Gentamicin

Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate the incorporation of amino acids at the stop codon and the production of full-length, often functional protein but defining the actual a...

ORGANISM(S): Homo sapiens (Human)

2024-10-29 | PXD039307 | Pride

Efficient Suppression of Premature Termination Codons by Engineered Pyrrolysine tRNAs

Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...

ORGANISM(S): Escherichia coli

2025-02-20 | PXD044322 | Pride

Proteomics Mutations Premature termination codons Trna Bacteria Gfp

Efficient Suppression of Premature Termination Codons by Engineered Chimeric Pyrrolysine tRNAs

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD044548 | Pride

Suppressor transfer rnas (sup-trnas) Premature termination codons (ptcs) Pyrrolysine trna scaffold suppressor-trnas (pass-trnas)

Transcriptomic analysis of premature termination codon mutation in the zebrafish gene psen2

PRJNA624323 | ENA

CRISPR-induced exon skipping is dependent on premature termination codon mutations.

Not available

S-EPMC6193291 | biostudies-literature