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ProteomicsMisincorporations at Artificially Constructed Termination Stop Codons in the Presence of the Amino Glycoside Gentamicin
Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate the incorporation of amino acids at the stop codon and the production of full-length, often functional protein but defining the actual a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-29 | PXD039307 | Pride
Lc-msms Cancer Aminoglycoside P53 protein Premature stop codon 
ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Escherichia coli 
2025-02-20 | PXD044322 | Pride
Proteomics Mutations Premature termination codons Trna Bacteria Gfp 
ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Chimeric Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044548 | Pride
Suppressor transfer rnas (sup-trnas) Premature termination codons (ptcs) Pyrrolysine trna scaffold suppressor-trnas (pass-trnas) 
Transcriptomics3' UTR length and mRNP composition determine endocleavage efficiencies at termination codons
We aimed to study the cleavage sites of nonsense-mediated mRNA decay (NMD) substrates. Therefore, we depleted the major exoribonuclease XRN1 in human cell culture, which degrades the 3' fragments generated by SMG6-mediated endonucleolytic cleavage. Different reporter mRNAs or endogenous NMD targets ...
ORGANISM(S): Homo sapiens 
2014-11-11 | E-MTAB-2907 | biostudies-arrayexpress
GenomicsProgrammed Repair of Disease-Causing UGA Premature Termination Codons in Mammalian Brain
Programmed Repair of Disease-Causing UGA Premature Termination Codons in Mammalian Brain
PRJNA1474329 | ENA
GenomicsEfficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs
Efficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs
PRJNA1160838 | ENA
UnknownEngineered transfer RNAs for suppression of premature termination codons.
Not available
S-EPMC6379413 | biostudies-literature
GenomicsCRISPR-free Programmable RNA pseudouridylation to suppress premature termination codons
CRISPR-free Programmable RNA pseudouridylation to suppress premature termination codons
PRJNA754430 | ENA
UnknownNonequivalence of Zfp423 premature termination codons in mice.
Not available
S-EPMC12505304 | biostudies-literature
UnknownPremature termination codons in modern human genomes.
Not available
S-EPMC4773809 | biostudies-literature
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