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ProteomicsMPP profiling in yeast - Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals a set of non-substrate proteins increased upon proteotoxic stress
The majority of mitochondrial preproteins is targeted via N-terminal presequences that are cleaved upon import into the organelle. The essential mitochondrial processing protease (MPP) is assumed to cleave the majority of incoming precursors. However, only few substrate proteins of MPP have been exp...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-10-14 | PXD002063 | Pride
Mitochondrial processing protease mpp Mitochondria Chafradic Mitochondrial stress response Presequence import pathway 
UnknownThe novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing.
Not available
S-EPMC5391191 | biostudies-literature
UnknownROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Not available
S-EPMC6363466 | biostudies-literature
TranscriptomicsLoss of function of the mitochondrial peptidase PITRM1 induces Alzheimer’s disease-like pathology and immune perturbations in human cerebral organoids
Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease involved in mitochondrial precursor processing and degradation, result in a slow-progressing syndrome characterized by cerebellar ataxia, psychotic episodes, and obsessive behavior, as well as cognitive decline. To investi...
ORGANISM(S): Homo sapiens 
2020-07-16 | GSE147047 | GEO
UnknownDELE1 tracks perturbed protein import and processing in human mitochondria.
Not available
S-EPMC8986780 | biostudies-literature
UnknownThe Impact of YabG Mutations on Clostridioides difficile Spore Germination and Processing of Spore Substrates.
Not available
S-EPMC12016784 | biostudies-literature
UnknownFunctional dissection of the dictyostelium discoideum dynamin B mitochondrial targeting sequence.
Not available
S-EPMC3578813 | biostudies-literature
UnknownThe Evolutionary History of Peptidases Involved in the Processing of Organelle-Targeting Peptides.
Not available
S-EPMC9291397 | biostudies-literature
ProteomicsMitochondrial surveillance activates the primary UPRmt
The mitochondrial unfolded protein response (UPRmt) is critical for protecting mitochondria against proteotoxic stress. Current UPRmt models propose that mitochondrial defects are detected by cytosolic surveillance mechanisms after release of damage into the cytosol. However, these findings are base...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-07 | PXD061965 | Pride
Reactive oxygen species Presequence processing Mitochondrial protein biogenesis Mitochondrial unfolded protein response 
UnknownMutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood.
Not available
S-EPMC5985287 | biostudies-literature
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