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ProteomicsStructural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
Presequence protease (PreP) degrades presequence peptides cleaved off from nuclear-encoded proteins and other aggregation-prone peptides, such as amyloid β (Aβ). PreP structures have only been determined in a closed conformation; thus, the mechanisms of substrate binding and selectivity remain elusi...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029542 | Pride
Amyloid peptide Hdxms Presequence protease Cryoem 
ProteomicsMPP profiling in yeast - Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals a set of non-substrate proteins increased upon proteotoxic stress
The majority of mitochondrial preproteins is targeted via N-terminal presequences that are cleaved upon import into the organelle. The essential mitochondrial processing protease (MPP) is assumed to cleave the majority of incoming precursors. However, only few substrate proteins of MPP have been exp...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-10-14 | PXD002063 | Pride
Mitochondrial processing protease mpp Mitochondria Chafradic Mitochondrial stress response Presequence import pathway 
GenomicsSaccharomyces cerevisiae strain:YPH499
Inducible inactivation of the mitochondrial presequence protease MPP in yeast
PRJNA498270 | ENA
UnknownThe novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing.
Not available
S-EPMC5391191 | biostudies-literature
UnknownStructural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Not available
S-EPMC8983764 | biostudies-literature
ProteomicsThe non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins
Mitochondrial protein import is essential for all eukaryotes. Here we show that the early diverging eukaryote Trypanosoma brucei has a non-canonical inner membrane (IM) protein translocation machinery. Besides TbTim17, the single member of the Tim17/22/23 family in trypanosomes, the presequence tran...
ORGANISM(S): Trypanosoma brucei 
2016-12-20 | PXD005484 | Pride
Trypanosoma brucei Rhomboid-like proteins Proteomics Silac Mitochondrial protein import Tbtim17 Rnai-mediated protein knockdown 
UnknownROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Not available
S-EPMC6363466 | biostudies-literature
UnknownIn vitro oxidative inactivation of human presequence protease (hPreP).
Not available
S-EPMC3589710 | biostudies-literature
UnknownMolecular basis of substrate recognition and degradation by human presequence protease.
Not available
S-EPMC4128088 | biostudies-literature
UnknownMechanism of oxidative inactivation of human presequence protease by hydrogen peroxide.
Not available
S-EPMC4258540 | biostudies-literature
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