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TranscriptomicsDysregulated TLR7 signaling drives anemia via development of hemophagocytic macrophages
The debilitating autoimmune disease Systemic Lupus Erythematosus (SLE) is closely associated with Toll-like receptor (TLR) 7 and type I interferon (IFN) activity in humans and in murine SLE-like disease. Two central manifestations of SLE affect the myeloid lineage of the immune system, myeloid expan...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-70520 | biostudies-arrayexpress
TranscriptomicsElucidating the etiology and molecular pathogenicity of infectious diarrhea by high throughput RNA sequencing
Diarrhea remains a major cause of death in children. Current diagnostic methods largely rely on stool culture and suffer from low sensitivity and inadequate specificity, often leading to inappropriate treatment. The objective of the present study was to use RNA sequencing (RNAseq) analysis to determ...
ORGANISM(S): Homo sapiens 
2015-06-04 | E-GEOD-69529 | biostudies-arrayexpress
TranscriptomicsRefining brucellosis diagnosis by blood transcriptional profiling
Diagnosis of brucellosis remains challenging for several reasons, including lack of culture sensitivity, nonspecific symptomatology, and high prevalence of positive serology in endemic areas. The main objectives of this study were to identify blood biomarkers specific to brucellosis compared to othe...
ORGANISM(S): Homo sapiens 
2015-06-06 | E-GEOD-69597 | biostudies-arrayexpress
TranscriptomicsA Blood Transcriptional Diagnostic Assay for Septicemic Melioidosis
Melioidosis, caused by Gram negative bacteria Burkholderia pseudomallei, is a major type of community-acquired septicemia in Southeast Asia and Northern Australia with high mortality and morbidity rate. More accurate and rapid diagnosis is needed for improving the management of septicemic melioidosi...
ORGANISM(S): Homo sapiens 
2015-06-04 | E-GEOD-69528 | biostudies-arrayexpress
TranscriptomicsResponse of IRF7-deficient peripheral blood mononuclear cells to pH1N1 influenza virus infection
IRF7 plays a critical role in the production and amplification of the antiviral type I and III interferon response. Autosomal recessive IRF7-deficiency resulted in life-threatening influenza disease in a 3-year-old child. We studied the impact of IRF7-deficiency in non-hematopoietic tissues (fibrobl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-66486 | biostudies-arrayexpress
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