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ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
GenomicsPromoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. Here, we find that depletion of the nucleosome remodeling and deacetylation (NuRD) complex in the cerebellar cortex by in v...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-57758 | biostudies-arrayexpress
GenomicsThe INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination
INO80 is an evolutionary conserved nucleosome remodelling complex that acts in transcription, replication and genome stability. It is required for resistance against genotoxic agents and involved in the repair of DNA double-strand breaks (DSB) by homologous recombination (HR). However, causes underl...
ORGANISM(S): Saccharomyces cerevisiae 
2017-05-14 | GSE95801 | GEO
UnknownProtein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules.
Not available
S-EPMC4190069 | biostudies-literature
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
Unknown'Fractional recovery' analysis of a presynaptic synaptotagmin 1-anchored endocytic protein complex.
Not available
S-EPMC1762330 | biostudies-literature
GenomicsCombinatorial codes of presynaptic organizer neurexins orchestrate precise olfactory axon targeting
Combinatorial codes of presynaptic organizer neurexins orchestrate precise olfactory axon targeting
PRJNA1046110 | ENA
GenomicsSaccharomyces cerevisiae
The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination
PRJNA378431 | ENA
UnknownCompartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.
Not available
S-EPMC6703276 | biostudies-literature
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