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ProteomicsProteomic profile of BxPC3 cells after RAD51 inhibition by treatment with BRC4
RAD51 protein is an evolutionarily conserved recombinase that plays a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. RAD51 inactivation by small molecules has been proposed as a strategy to impair the BRCA2/RAD51 binding and, ultimately, the HR pathway, with ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042696 | Pride
Proteomie Rad51 Bxpc3 cells Brc4. 
ProteomicsInvestigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer Through Enantiomer Differential Activity
The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue for intervention. We previously showed that co...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054120 | Pride
Anticancer drugs  homologous recombination  parp inhibitors  protein-protein small molecule inhibitors  parpi resistance  within-pathway synthetic lethality (wpsl) 
UnknownInvestigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.
Not available
S-EPMC11911456 | biostudies-literature
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