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MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
UnknownCoverage Parity And Racial And Ethnic Disparities In Mental Health And Substance Use Care Among Medicare Beneficiaries.
Not available
S-EPMC10910600 | biostudies-literature
TranscriptomicsTranscription profiling of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
A study of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
ORGANISM(S): Rattus norvegicus 
2006-12-10 | E-MEXP-515 | biostudies-arrayexpress
GenomicGenome-Wide Association Study of Anorexia Nervosa

Twin studies are consistent with substantial heritability in anorexia nervosa (AN), although detecting and confirming individual risk alleles has been difficult, due to small effects of single alleles and limited samples in prior studies.

Methods: 1105 AN DNA samples obtained in a m...

phs000679 | dbGaP
UnknownPhysician Group Practices Accrued Large Bonuses Under Medicare's Bundled Payment Model, 2018-20.
Not available
S-EPMC12668274 | biostudies-literature
UnknownDeath spiral of the legacy grid: A game-theoretic analysis of modern grid defection processes.
Not available
S-EPMC10074203 | biostudies-literature
TranscriptomicsGene expression profiling of constitutive activation of Smoothened in the mouse uterus
In order to gain a better understanding of Ihh action during embryo implantation, we constitutively activated Smo in the murine uterus using the PRcre mouse model (PRcre/+SmoM2+; SmoM2). Female SmoM2 mice were infertile. They exhibited normal serum progesterone levels and normal ovulation, but ova ...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-17263 | biostudies-arrayexpress
ProteomicsStreptamidine, streptapyrimidone and spyrimidone production in Streptomyces albidoflavus J1074 and S. coelicolor M1146-pCAPSalbC
Data used to evaluate temporal progression of streptamidine, streptapyrimidone, spyrimidone and glycosylated spyrimidone production in Streptomyces albidoflavus J1074 and the heterologous host Streptomyces coelicolor M1146 expressing the streptamidine (ami) cluster. LC-MS/MS data used to characteris...
ORGANISM(S): Streptomyces Albidoflavus J1074 Streptomyces Coelicolor M1146 
2024-04-18 | MSV000094563 | MassIVE
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
ProteomicsHigh-density CRISPRi screens reveal adaptive transcriptional gradients in cyanobacteria
Cyanobacteria are the oldest form of photosynthetic life and contribute to primary production in nearly every habitat, from permafrost to hot springs. Despite longstanding interest in the biochemical basis of environmental adaptation in these microbes, it remains poorly understood. Here we used a hi...
ORGANISM(S): Synechococcus Sp. Pcc 7002 (ncbitaxon:32049) 
2024-04-18 | MSV000094564 | MassIVE
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