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ProteomicsProteomic Analysis of Arylamine N-Acetyltransferase 1 Knockout Breast Cancer Cells
Description A phase II metabolic enzyme, NAT1 is frequently upregulated in breast cancers. Previous studies have shown that inhibition or depletion of NAT1 in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast ca...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035953 | Pride
Breast cancer Nat1 Mda Tmt10plex 
ProteomicsOptimization of Proteomics Sample Preparation for Forensic Analysis of Skin Samples
We present an efficient protein extraction and in-solution enzymatic digestion protocol optimized for mass spectrometry-based proteomics studies of human skin samples.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD022720 | Pride
Proteomics  sample preparation  protein extraction  trypsin digestion  surfactants  human forensics 
ProteomicsThe proteomic and transcriptomic landscapes altered by Rgg2/3 activity in Streptococcus pyogenes
Streptococcus pyogenes, otherwise known as Group A Streptococcus (GAS), is an important and highly adaptable human pathogen with the ability to cause both superficial and severe diseases. Understanding how S. pyogenes senses and responds to its environment will likely aid in determining how it cause...
ORGANISM(S): Streptococcus pyogenes NZ131 
2022-10-04 | PXD033703 | Pride
Rgg3 Streptococcus pyogenes Rgg2 Quorum sensing 
ProteomicsDysregulation of muscle myosin biochemical states in X-linked myotubular myopathy
Pathogenic variants in MTM1 are associated with a severe, congenital muscle disorder called X-linked myotubular myopathy. Here, we aimed to assess the effect of mavacamten (myosin ATPase inhibitor) treatment in a mouse model for X-linked myotubular myopathy (Mtm1-KO) using the global untargeted prot...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-31 | PXD068387 | Pride
Skeletal muscle  myotubular myopathy  mtm1  myosin 
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