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TranscriptomicsProfiling of the transcriptome during culture-induced activation of rat hepatic stellate cells.
Gene expression was determined in primary rat hepatic stellate cells during the in vitro activation process in freshly isolated (4h), quiescent (1d), early activated (3d) and fully activated (7d) hepatic stellate cells. The cells were isolated from the liver using density centrifugation and cultured...
ORGANISM(S): Rattus norvegicus 
2017-10-23 | E-MTAB-5404 | biostudies-arrayexpress
TranscriptomicsIn vitro activation and reversion of human primary hepatic stellate cells
Liver fibrosis is characterized by the excessive formation and accumulation of matrix proteins as a result of wound healing in the liver. A main event during fibrogenesis is the activation of the liver resident quiescent hepatic stellate cell (qHSC). Recent studies suggest that reversion of the acti...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-GEOD-68001 | biostudies-arrayexpress
TranscriptomicsGene expression profiling and secretome analysis differentiate Adult-Derived Human Liver Stem/progenitor Cells and human hepatic stellate cells
Adult-derived human liver stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal fraction. The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal phenotype. Hepatic stellate cells (HSC) derived from the liver non-parenchymal fraction present a c...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-49995 | biostudies-arrayexpress
MetabolomicsGut microbiota ameliorates hepatic fibrosis through modulating intestinal bile acid metabolism and hepatocyte pyroptosis (Hepatic fibrosis serum+feces)

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. dista...

2023-03-17 | MTBLS6728 | MetaboLights
TranscriptomicsTranscriptome of human liver cells and culture-activated hepatic stellate cells
The molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. In addition, the gene expression changes associated with activation of primary human hepatic stellate cells, a key event during fibrogenesis, remain poorly characterized. Here, we provide the transript...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-68000 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
Hepatic stellate cells are involved in the development of hepatic fibrosis. We here perform transcriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in ...
ORGANISM(S): Mus musculus 
2019-04-07 | E-MTAB-7054 | biostudies-arrayexpress
ProteomicsHuman hepatic stellate cell-derived extracellular vesicles LC-MSMS
Activation and migration of hepatic stellate cells (HSCs) followed by matrix deposition are characteristics of liver fibrosis. Several studies have shown the importance of hepatocyte and endothelial cell-derived extracellular vesicles (EVs) in liver pathobiology. However, less is known about the rol...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD007258 | Pride
Lc-msms Hepatic stellate cells Extracellular vesicles Liver 
TranscriptomicsCUT&Tag analysis of H3K9Me3 binding quiescent and activated primary mouse hepatic stellate cells
Contrasting H3K9Me3 binding site number and localisation between activated and quiescent hepatic stellate cells to identify regulation of gene repression.
ORGANISM(S): Mus musculus 
2023-10-11 | E-MTAB-12907 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of quiescent and activated primary mouse hepatic stellate cells
Contrasting transcript expression between activated and quiescent hepatic stellate cells to identify key gene networks for the activation process.
ORGANISM(S): Mus musculus 
2023-10-11 | E-MTAB-12909 | biostudies-arrayexpress
TranscriptomicsATAC-seq analysis of quiescent and activated primary mouse hepatic stellate cells
Contrasting chromatin accessibility between activated and quiescent hepatic stellate cells to identify key gene networks for the activation process.
ORGANISM(S): Mus musculus 
2023-10-11 | E-MTAB-12908 | biostudies-arrayexpress
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