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MetabolomicsComparative metabolomics analysis of bronchial epithelium during barrier establishment after allergen exposure

BACKGROUND: Several studies have shown a correlation between an altered metabolome and respiratory allergies. The epithelial barrier hypothesis proposes that an epithelial barrier dysfunction can result in allergic diseases development. Der p 1 allergen from house dust mite is a...

2023-08-22 | MTBLS1755 | MetaboLights
TranscriptomicsGene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.
mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in b...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-16008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.
Human bronchial epithelial cells were treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2111 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells from normal and asthmatic individuals to investigate rhinovirus-induced modulation of gene expression
Human Rhinovirus (HRV) infection can trigger exacerbations of asthma. Understanding of the mechanisms provoking airway inflammation and remodeling in asthma, as well as the pathogenic mechanisms of HRV infection and its association with asthma exacerbations, may offer significant opportunities for i...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-13396 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human bronchial epithelial cells stimulated with IL-13
Human bronchial epithelial cells were stimulated without or with 100 ng/mL IL-13 for 24 hours.
ORGANISM(S): Homo sapiens 
2012-07-05 | E-MEXP-3353 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of bronchosphere cultures of primary human bronchiolar epithelial cells
Primary human bronchial epithelial cells were transduced with control or hYAP(S127A) lentivirus in sphere forming conditions. Bronchospheres were harvested on day 18-20 for RNAseq analysis Passage 1 Primary HBECs from 2 independent donors were transduced with control or hYAP lentivirus. 48 hours pos...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-61626 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with interferon gamma and/or dexamethasone
RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1815 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression from bronchial epithelial cell samples of current and never smokers.
MicroRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy from healthy current and never smoker volunteers in order to determine the effect of cigarette smoke exposure on airway epithelial microRNA expression Keywords: Global microRNA expression profiling Bronchial ...
ORGANISM(S): Homo sapiens 
2009-01-28 | E-GEOD-14634 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelial cells sampled at multiple time points to examine mucociliary differentiation
Microarray analysis was performed to identify transcriptional changes that occur during mucociliary differentiation of human primary bronchial epithelial cells cultured at an air-liquid interface (ALI). Experiment Overall Design: Cells from three different donors were cultured and collected at 11 di...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-5264 | biostudies-arrayexpress
TranscriptomicsSystems biology approaches reveal low-dose effects of nanoparticles
Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do ...
ORGANISM(S): Homo sapiens 
2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress
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