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TranscriptomicsDissection of human fibroblast populations by lung regions: genomic differences and functional pathway analysis
ABSTRACT Background: Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of alpha-SMA. The scope of the differences and the mechanisms driving them are unknown. We hypothesized that the distinct ...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-19362 | biostudies-arrayexpress
TranscriptomicsGenomic differences distinguish the myofibroblast phenotype of distal lung from airway fibroblasts
ABSTRACT Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of a-smooth muscle actin (a-SMA). The scope of the differences and the mechanisms driving them are unknown. To determine whether disti...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-27335 | biostudies-arrayexpress
TranscriptomicsExpression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts
In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compare...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26146 | biostudies-arrayexpress
TranscriptomicsRNA-seq time series of lung epithelial and lung mesenchymal cells in a novel co-culture model of lung fibrosis
The interaction of lung epithelial and lung mesenchymal cells (fibroblasts) was investigated in a novel co-culture model of human pulmonary fibrosis. Remarkably, co-culturing both cell types induced cell-type-specific responses, including fibroblast-to-myofibroblast differentiation and epithelial-to...
ORGANISM(S): Homo sapiens 
2022-10-03 | E-MTAB-11832 | biostudies-arrayexpress
TranscriptomicsGene expression in lung fibroblasts
Pulmonary fibrosis is a chronic, progressive, and lethal interstitial lung disease. It is characterized by extracellular matrix deposition, fibroblast proliferation, and accumulation. Fibroblasts from normal or UIP histology were cultured and analyzed. Keywords: Fibroblasts from normal histology lun...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-10921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cancer-associated fibroblasts treated with dasatinib
Effect of Dasatinib on primary cancer-associated fibroblasts from lung cancer specimens.
ORGANISM(S): Homo sapiens 
2011-01-12 | E-MEXP-2546 | biostudies-arrayexpress
TranscriptomicsmiRNA in human lung fibroblasts
By employing miRCURY™ LNA array, we have identified a subset (79) of the total number of miRNAs that are differentially expressed in TGF beta1-treated human lung fibroblasts MRC-5 cells, as compared to untreated control cells To know the differential expression of miRNA in human lung fibroblasts aft...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43992 | biostudies-arrayexpress
ProteomicsSSc biomarkers detection in the secretome of TGF1-activated primary human lung fibroblasts.
TGFβ1 is a profibrotic mediator that contributes to a broad spectrum of pathologies, including pulmonary fibrosis (PF). However, the secretome of TGFβ1-stimulated primary human normal lung (NL) fibroblasts has not been well characterized. Using fluorescent 2-dimensional gel electrophoresis (2D-PAGE)...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023862 | Pride
Tgfbeta Fibroblasts Secretome 
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-22874 | biostudies-arrayexpress
TranscriptomicsPrognostic Gene Expression Signature of Carcinoma Associated Fibroblasts in Non-Small Cell Lung Cancer [methylation profiling]
The tumor microenvironment strongly influences cancer development, progression and metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC). We established primary culture...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-27284 | biostudies-arrayexpress
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