Primary mouse neuron

Show results for

Transcriptomics (860)
Unknown (629)
Genomics (252)
Proteomics (111)
Metabolomics (15)
Other (3)
Methylation profiling (1)
Multiomics (1)

Organisms

Mus musculus (714)
Homo sapiens (189)
Andropogon gerardi (76)
Bacteria (76)
Bartonella quintana JK 31 (76)
Canis lupus familiaris (76)
Clavibacter nebraskensis NCPPB 2581 (76)
Cnidaria (76)
Ensifer adhaerens (76)
Halictus scabiosae (76)
Human alphaherpesvirus 1 strain 17 (76)
Human alphaherpesvirus 1 strain KOS (76)
Rattus norvegicus (31)
Drosophila melanogaster (7)
Arabidopsis thaliana (7)
Caenorhabditis elegans (4)
Candida albicans (4)
Danio rerio (4)
mixed sample (3)
Callithrix jacchus (2)
Heterocephalus glaber (2)
Bos taurus (2)
Anopheles stephensi (1)
Pan troglodytes (1)
Selaginella moellendorffii (1)
Pan paniscus (1)
Macaca fascicularis (1)
Rattus rattus (1)
Human alphaherpesvirus 1 (1)
Fusarium sinicum (1)

Organisms

Mus musculus (126)
Homo sapiens (10)
Rattus norvegicus (2)

Repository

biostudies-arrayexpress (877)
ENA (157)
geo (80)
pride (76)
MassIVE (22)
MetaboLights (15)
jPOST (5)
EGA (4)
iProX (4)
PanoramaPublic (2)
GPMDB (1)

Tissue

Brain (37)
Cell culture (20)
Neuron (15)
Primary neuron (12)
Primary cell (11)
Hippocampal neuron (7)
Microglial cell (5)
Astrocyte (4)
Cerebral cortex neuron (3)
Cerebrospinal fluid (3)
Permanent cell line cell (3)
Primary cell line cell (3)
Cerebellar neuron (2)
Early embryonic cell (2)
Embryo (2)
Neuron of cerebral cortex (2)
Oligodendrocyte (2)
Astrocyte of the spinal cord (1)
Central nervous system neuron (1)
Cerebellar granule cell (1)
Cerebral cortex (1)
Cerebral cortex pyramidal neuron (1)
Cortical interneuron (1)
Dorsal root ganglion (1)
Electrically active cell (1)
Glutamatergic neuron (1)
Hippocampus (1)
Kidney (1)
Layer of hippocampus (1)
Primary cerebral cortical neuronï¿½ (1)

Disease

Amyotrophic lateral sclerosis (5)
Alzheimer's disease (5)
Parkinson's disease (5)
Normal (4)
Spinal muscular atrophy (2)
Breast cancer (2)
Neuroblastoma (2)
Disease free (2)
Frontotemporal dementia (2)
Multiple sclerosis (1)
SMARD1 (1)
Primary medulloblastoma (1)
IRAK-4 Q293X mutation (1)
Spinal muscular atrophy (NCI Metathesaurus C0026847) has DiseaseStaging postsymptomatic (1)
Bordetella pertussis inoculated (1)
Normal (1)
Temporal lobe epilepsy (1)
Control (1)
Not Available (1)
Amyotrophic lateral sclerosis type 10 (1)
Charcot-Marie-Tooth disease (1)
Fragile X syndrome (1)
Herpes simplex (1)
Ischemia (1)
Neurodegenerative disease (1)
Neurological dysfunction (1)
Pain (1)
Relapsing-remitting multiple sclerosis (1)
Sensory peripheral neuropathy (1)
Tauopathy (1)

Technology Type

Mass Spectrometry (76)
Shotgun proteomics (49)
Mass spectrometry (13)
Affinity purification coupled with mass spectrometry proteomics (13)
Gel-based experiment (9)
Bottom-up proteomics (7)
SWATH MS (6)
Data-dependent acquisition (3)
Data-independent acquisition (3)
Mass spectrometry assay (2)
DiaPASEF (2)
ILLUMINA, Illumina HiSeq 2500 (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Affinity proteomics (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
HDMSE (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (54)
Illumina HiSeq 2500 (35)
NextSeq 500 (26)
Illumina HiSeq 4000 (21)
Illumina HiSeq 2000 (16)
NextSeq 550 (10)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
Illumina Genome Analyzer II (2)
Illumina NovaSeq X (2)
Illumina HiSeq 1500 (2)
Illumina HiSeq 3000 (2)
Bravo automated liquid handling robot station (Agilent) (1)
STAR v2.5.3a, rpkmforgenes, RSeQC 2.6.1 (1)
Illumina Nextera XT index kits (Set A–D) (1)
Oligo(dT) primer and SuperScript II reverse transcriptase (ThermoFisher Scientific), TapeStation 4200 or 2100 Bioanalyzer with a DNA High Sensitivity chip (Agilent Biotechnologies) (1)
Aria III (BD Biosciences) (1)
-- (1)
Chromium Next GEM Chip G (1)
10X v3 (1)
ProFlex PCR system (1)
10X Genomics Chromium v3.1 with multiplexing kit (1)
Qubit 4.0 and TapeStation (1)
Affymetrix GeneChip® Scanner 3000 7G (1)
See protocol (1)
Element AVITI (1)
Microcentrifuge (1)
MouseWG-6_V2_0_R3_11278593_A (1)
SMARTerTM Ultra Low RNA Kit (1)
Fluidigm C1 (1)
Linux computer (1)

Publication Date

2015 (115)
2014 (109)
2013 (107)
2012 (79)
2016 (75)
2011 (71)
2010 (55)
2025 (51)
2008 (51)
2023 (49)
2021 (47)
2022 (42)
2026 (35)
2024 (29)
2020 (29)
2018 (26)
2009 (26)
2007 (25)
2017 (21)
2019 (20)
2006 (7)
2005 (4)
2004 (2)
2003 (1)

CHEBI ID

CHEBI:17992 (2)
CHEBI:26984 (2)
CHEBI:73688 (2)
CHEBI:17822 (2)
CHEBI:26271 (2)
CHEBI:25094 (2)
CHEBI:18237 (2)
CHEBI:22660 (2)
CHEBI:22653 (2)
CHEBI:18186 (2)
CHEBI:22652 (2)
CHEBI:28300 (2)
CHEBI:24898 (2)
CHEBI:25017 (2)
CHEBI:28842 (2)
CHEBI:15428 (2)
CHEBI:17148 (2)
CHEBI:17754 (2)
CHEBI:16610 (2)
CHEBI:15741 (2)
CHEBI:6650 (2)
CHEBI:28044 (2)
CHEBI:27266 (2)
CHEBI:18183 (2)
CHEBI:77065 (2)
CHEBI:16449 (2)
CHEBI:15996 (2)
CHEBI:17552 (2)
CHEBI:15422 (2)
CHEBI:18012 (2)

Metabolite Name

NADPH (3)
Kynurenic acid (3)
Inosine (3)
L-Glutathione oxidized (2)
2,3-Diphosphoglyceric acid (2)
Thiamine pyrophosphate (2)
GTP (2)
Idebenone (2)
2'-O-Methyluridine (2)
P-Anisic acid (2)
DUMP (2)
Acetyl-CoA (2)
Pyruvic acid (2)
Taurodeoxycholic acid (2)
Methylimidazoleacetic acid (2)
UTP (2)
Tryptophan (2)
Serine (2)
Proline (2)
Lysine (2)
IMP (2)
FAD (2)
Citrulline (2)
ATP (2)
Aspartate (2)
Asparagine (2)
Arginine (2)
AMP (2)
3-phosphoglycerate (2)
Histidine (2)

First Public Date

2014 (25)
2026 (23)
2024 (20)
2025 (18)
2023 (15)
2022 (15)
2020 (10)
2017 (8)
2021 (7)
2018 (6)
2015 (5)
2019 (4)
2016 (1)

Study type

Transcription profiling by array (449)
RNA-seq of coding RNA (202)
ChIP-seq (69)
RNA-seq of coding RNA from single cells (41)
Methylation profiling by high throughput sequencing (14)
RNA-seq of non coding RNA (14)
Other (12)
Animal - High-throughput sequencing (10)
ChIP-chip by tiling array (9)
Methylation profiling by array (7)
ATAC-seq (5)
Unknown experiment type (4)
Comparative genomic hybridization by array (4)
RNA-seq of total RNA (4)
ChIP-chip by array (3)
Genotyping by array (3)
Transcription profiling by RT-PCR (3)
Transcription profiling by SAGE (2)
Cell line - Single-cell sequencing (2)
Baseline (2)
Animal - One-color microarray (2)
Single nucleus RNA sequencing (2)
Proteomic profiling by array (2)
CUT&RUN (2)
Differential (1)
Animal - Single-cell sequencing (1)
Cell line - One-color microarray (1)
High-throughput sequencing (1)
CLIP-seq (1)
MicroRNA profiling by high throughput sequencing (1)

Release Date

2015 (133)
2014 (124)
2013 (119)
2016 (108)
2025 (103)
2012 (94)
2023 (89)
2021 (82)
2011 (80)
2022 (75)
2024 (71)
2010 (62)
2019 (57)
2018 (56)
2020 (55)
2008 (51)
2017 (48)
2009 (31)
2026 (24)
2007 (23)
2006 (9)
2005 (4)
2004 (3)
2003 (2)
2002 (1)
2000 (1)
1998 (1)

Lab affiliation

CECAD Excellence Center, University of Cologne, Germany, D-50931 Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany, D-50931 (2)
Cell Biology and Physiology, University of North Carolina at Chapel Hill, North Carolina, USA (2)
Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA (2)
Neuroproteomics DZNE Munich Feodor-Lynen-Str. 17 81377 Munich Germany (2)
Associate Professor, University of Maryland College Park, MD 20742 (1)
Boston University (1)
Cellzome (1)
Centre for Discovery Brain Sciences, University of Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, UK (1)
Core Unit Proteomics, BIH at Charite and MDC, Robert Roessle Strasse 10, 13125 Berlin (1)
DZNE Munich Neuroproteomics Feodor-Lynen Str. 17 81377 Munich Germany (1)
DZNE Munich Neuroproteomics Feodor-Lynen-Str. 17 81377 Munich Germany (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (1)
Dana Farber Cancer Institute, Boston, MA Harvard Medical School, Boston, MA (1)
Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute Cell Signalling Research Laboratories The University of Melbourne Parkville, Victoria 3010, Australia (1)
Department of Biochemistry and Molecular Biology The University of Melbourne Australia (lab head) (1)
Department of Biochemistry and Molecular Biology and Córdoba Maimónides Institute for Biomedical Research (IMIBIC), University of Córdoba (1)
Department of Biomedical Sciences University of Padova via Ugo Bassi, 58b - 35130 - Padova - Italy (1)
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, NSW, 2109, Australia (1)
Department of Cell Biology, Harvard Medical School (1)
Department of Chemistry & Biochemistry, University of Maryland, College Park, MD, USA (1)
Department of Chemistry and Biotechnology Tallinn University of Technology Estonia (1)
Department of Life Sciences, University of Bath, UK (1)
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research,Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan 1085,1081 HV Amsterdam, The Netherlands (1)
Department of Molecular and Cellular Neurobiology, Center of Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands (1)
Department of Neurobiology, Harvard Medical School; Boston, USA. (1)
Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China (1)
Department of Neurological Surgery, Washington University in St. Louis School of Medicine (1)
Department of Neurology, Emory University, Atlanta, GA 30322, US (1)
Department of Neuroscience, Tufts University School of Medicine (1)
Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA (1)

Previous page
1 / 188
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 188
Next page

Sort by:

Relevance

Page size

STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex

The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...

ORGANISM(S): Mus musculus

2013-09-19 | E-GEOD-50993 | biostudies-arrayexpress

RNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.

This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...

ORGANISM(S): Mus musculus

2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress

Transcriptomic profiling of spinal and bulbar muscular atrophy cultured embryonic motor neurons

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy’s Disease, is a slowly progressive adult-onset neuromuscular disease which results from a polyglutamine (polyQ) encoding CAG repeat expansion within the androgen receptor gene (AR). Despite the ubiquitous expression of the androgen rec...

ORGANISM(S): Mus musculus

2019-05-02 | E-MTAB-6986 | biostudies-arrayexpress

1,25-dihydroxyvitamin D3-induced genes in mouse mixed neuron-glial cell cultures

Transcriptomic response of mouse mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin D3 6 samples are analysed with three biological replicates in two conditions, control versus 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)

ORGANISM(S): Mus musculus

2013-03-25 | E-GEOD-41184 | biostudies-arrayexpress

Global transcriptional analysis of mouse fibroblasts, chemically-induced neurons (neuron-like cells) from mouse fibroblasts and mouse primary cortical neurons by RNA-seq

Recently, direct reprogramming between divergent lineages has been achieved by introducing cell-fate-determining transcription factors. This progress may provide alternative cell resources for drug discovery and regenerative medicine. However, the genetic manipulation may limit the future applicatio...

ORGANISM(S): Mus musculus

2015-08-12 | E-GEOD-68715 | biostudies-arrayexpress

Investigating the effect of Aurora Kinase B inhibition in WT and CDH1 mutant primary neuron cultures

Primary cultures of mouse cerebellar granule neurons at DIV2 that were either WT or Cdh1 mutant were treated with and without the Aurora B inhibitor Barasertib and assessed by phosphoproteomic analysis

ORGANISM(S): Mus musculus (Mouse)

2023-10-12 | PXD045116 | Pride

mRNA-seq of neuronal compartments with perturbed mRNA degradation machinery in mouse primary cortical neurons (mPCN)

We have perturbed mRNA degradation machinery and investigated the change in subcellular localization of mRNA in mouse primary cortical neurons (mPCNs). Mutant mPCN line harbouring a ponasteroneA-inducible heterozygous dominant-negative Caf1 (dnCaf1) was generated, separated into neuronal compartment...

ORGANISM(S): Mus musculus

2022-11-14 | E-MTAB-11572 | biostudies-arrayexpress

Transcriptome profiling of severe spinal muscular atrophy mouse embryonic stem cell-derived motor neurons

Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected ...

ORGANISM(S): Mus musculus

2014-09-08 | E-GEOD-56284 | biostudies-arrayexpress

Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach perspective of human cancers.

Swiss-Webster B mouse postnatal day 4-5 primary cerebellar culture (pooled from litter mates) treated with sonic hedgehog (Shh), controls (veh), growth arrested (arrest), cycloheximide (cyc) for 1, 3 and 24 hours. Different treatment conditions with biological replicates. Mouse cerebellar granule ce...

ORGANISM(S): Mus musculus

2013-09-06 | E-GEOD-50606 | biostudies-arrayexpress

Single-cell whole-genome sequencing of primary mouse cerebellar granule neuron progenitors

PRJEB54869 | ENA

Previous page
1 / 188
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 188
Next page

Sort by:

Relevance

Page size

1872 Results

Show results for

Organisms

Organisms

Repository

Tissue

Disease

Technology Type

Instrument Platform

Publication Date

CHEBI ID

Metabolite Name

First Public Date

Study type

Release Date

Lab affiliation

Tags

OmicsDI is part of the ELIXIR infrastructure

Tweets