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ProteomicsRat Cortical Primary Neuronal Culture with NRN1 Protein Treatment
Cortical rat neuronal culture, lysis and proteolytic digestion Primary rat cortical neurons were generated from E18 Sprague-Dawley rat embryos with minor modifications (Swanger, Mattheyses et al. 2015, Henderson, Greathouse et al. 2019). Neurons were cultured at a density of 4x105 cells per well in...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD040867 | Pride
Rat primary cortical neurons Nrn1 Neuroproteomics 
TranscriptomicsPHF6 knockdown in rat cortical neurons
E18 embryonic rat cortical neurons cultured in vitro are infected with lentivirus expressing control or PHF6shRNA-2, and harvested 5 days after infection pLL3.7 lentivirus expressing control or PHF6shRNA-2 was generated in 293T cells and concentrated using ultracentrifuge. In vitro cultured cortical...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-45953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat depolarization induced gene from primary cortical neuron
Activation of neurons is one of the fundamental events for the functioning of nervous system. Neuronal activation relays information to next neurons. On the other hand, the activated neurons themselves are also influenced by neuronal activation. Depending on the type and condition of neuronal activa...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4472 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat primary cortical neurons exposed to anesthetics
Inhaled anesthetics produce many effects and bind to a large number of brain proteins, but it is not yet clear if this is accompanied by widespread changes in gene expression of the biological targets. Such changes in expression might implicate functionally important targets from the large pool of ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-2982 | biostudies-arrayexpress
TranscriptomicsSingle cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity
Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclea...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-69790 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Fus
To clarify the functional properties of FUS, we established the differentially expressed alternative exons in FUS-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary cortical neuron infected with lentivirus expressing shRNA against mouse ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-36153 | biostudies-arrayexpress
ProteomicsCell surface proteome in rat cortical neuron
Here, using proteomic analysis of primary rat cortical neurons subjected to either sh-SCR control or sh-Vps35l knockdown, we provide a data-rich resource that reveals novel molecular insights into how VPS35Lregulates the membrane proteome.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-05 | PXD064824 | Pride
Primary rat cortical neuron Vps35l Cell surface proteome Tmt label Lc-ms/ms 
TranscriptomicsTranscription profiling of rat control subplate neurons with few synapses and cocultured subplate neurons with induced synaptogenesis
The transcriptional events accompanying synaptogenesis are largely unknown, or have been studied in systems in which synapse formation occurs gradually over time. With a system in which synaptogenesis is synchronized and controllable, molecular or biochemical techniques can be used to examine cellu...
ORGANISM(S): Rattus norvegicus 
2008-11-29 | E-GEOD-8318 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Cugbp1
To clarify the functional properties of Cugbp1, we established the differentially expressed alternative exons in Cugbp1-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary motor neuron infected with lentivirus expressing shRNA against mou...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-46147 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Tdp-43
To clarify the functional properties of Tdp-43, we established the differentially expressed alternative exons in Tdp-43-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary motor neuron infected with lentivirus expressing shRNA against mou...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-46146 | biostudies-arrayexpress
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