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TranscriptomicsRNAseq of PRMT4KD in human cord blood derived CD34+ cells
Defining the role of epigenetic regulators in normal hematopoiesis has become critically important, as recurrent mutations or aberrant expression of these genes has been identified in both myeloid and lymphoid hematological malignancies. We have found that PRMT4, a type I arginine methyltransferase,...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-46056 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls
Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their l...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-21606 | biostudies-arrayexpress
TranscriptomicsCARM1/PRMT4 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis
We investigated the role of PRMT4 in normal and malignant hematopoiesis. We found that knockdown of PRMT4 impairs cell cycle progression, induces apoptosis, and downgretulateds E2F target genes in leukemia cell lines, identifying several mechanisms for the leukemia-specific dependence on PRMT4.
ORGANISM(S): Homo sapiens 
2018-06-10 | GSE103528 | GEO
UnknownProtein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.
Not available
S-EPMC9522923 | biostudies-literature
UnknownPRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.
Not available
S-EPMC4073674 | biostudies-literature
UnknownPRMT4 is a novel coactivator of c-Myb-dependent transcription in haematopoietic cell lines.
Not available
S-EPMC3591284 | biostudies-literature
UnknownTP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Not available
S-EPMC5915086 | biostudies-literature
UnknownIdentification and in silico structural analysis of Gallus gallus protein arginine methyltransferase 4 (PRMT4).
Not available
S-EPMC5715347 | biostudies-literature
ProteomicsMass spectrometry identification of PPARγ methylation sites
Purified recombinant PPARγ-Flag and PRMT4-His were used for in vitro methyltransferase assay.We separated purified methylated PPARγ proteins by SDS-PAGE, visualized them by staining with Coomassie blue, protein lanes were cut into pieces about 1 mm3, and followed further destained.
ORGANISM(S): Homo Sapiens 
2022-06-27 | PXD034929 |
UnknownTranscriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4.
Not available
S-EPMC3752545 | biostudies-literature
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