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TranscriptomicsIGH analysis in pro-B cells with H3K4me3, H3K4me2 and H3K9ac
STAT5 and IL-7 signaling are thought to control B-lymphopoiesis by regulating key transcription factor genes and activating VH gene segments at the Igh locus. Using conditional mutagenesis, we demonstrate that transgenic Bcl2 expression rescued the development of Stat5-deleted pro-B cells by compens...
ORGANISM(S): Mus musculus 
2010-07-28 | E-GEOD-18278 | biostudies-arrayexpress
GenomicsIGH analysis in pro-B cells with H3K4me3, H3K4me2, H3K9ac, H3K27me3, Pax5 and CTCF [ChIP-Seq]
VH-DJH recombination of the immunoglobulin heavy-chain (Igh) locus is temporally and spatially controlled during early B-cell development, and yet no regulatory elements other than the VH gene promoters have been identified throughout the entire 2.5-Mb VH gene cluster. Here we discovered novel regul...
ORGANISM(S): Mus musculus 
2011-02-11 | E-GEOD-27214 | biostudies-arrayexpress
GenomicsChIP-seq for CTCF and Rad21 in Rag1M-bM-^HM-^R/M-bM-^HM-^R pro-B cells
Genome-wide ChIP data of CTCF and Rad21 binding in Rag1M-bM-^HM-^R/M-bM-^HM-^R pro-B cells CTCF and Rad21 binding in Rag1M-bM-^HM-^R/M-bM-^HM-^R pro-B
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-26257 | biostudies-arrayexpress
TranscriptomicsChip-chip from pro-B cells with H3K4me3, H3K4me2 and H3K9ac
The transcription factor Pax5 represses B-lineage-inappropriate genes and activates B-cell-specific genes in B-lymphocytes. Here we have identified 170 novel Pax5-activated genes. Conditional mutagenesis demonstrated that the Pax5-regulated genes require continuous Pax5 activity for normal expressio...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-15145 | biostudies-arrayexpress
TranscriptomicsChip-chip from pro-B cells with H3K4me3, H3K4me2 and H3K9ac
The transcription factor Pax5 represses B-lineage-inappropriate genes and activates B-cell-specific genes in B-lymphocytes. Here we have identified 170 novel Pax5-activated genes. Conditional mutagenesis demonstrated that the Pax5-regulated genes require continuous Pax5 activity for normal expressio...
ORGANISM(S): Mus musculus 
2007-08-23 | E-GEOD-8472 | biostudies-arrayexpress
GenomicsRNA-seq of CDKN2A and EZH2-deficient pro-B and DN3 lymphocyte progenitors
RNA-seq of CDKN2A and EZH2-deficient pro-B and DN3 lymphocyte progenitors
PRJNA553271 | ENA
GenomicsRetrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro B cells
The establishment of distinct transcription programs during development is controlled by transcription factor networks acting in specific chromatin environments. The H3K9me3-specific histone methyltransferase Setdb1 impacts on transcriptional regulation by repressing both developmental genes and ret...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-77636 | biostudies-arrayexpress
GenomicsNon-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
Non-coding sense and antisense germline transcription within the immunoglobulin heavy chain locus precedes V(D)J recombination and has been proposed to be associated with Igh locus accessibility, although its precise role remains elusive. However, no global analysis of germline transcription through...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40822 | biostudies-arrayexpress
TranscriptomicsNon-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
Non-coding sense and antisense germline transcription within the immunoglobulin heavy chain locus precedes V(D)J recombination and has been proposed to be associated with Igh locus accessibility, although its precise role remains elusive. However, no global analysis of germline transcription through...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40984 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of fetal liver and adult bone marrow pro-B cells
We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression profiles of pro-B cells sorted from fetal liver and adult bone marrow in order to gain insight into changes in miRNA expression during B cell ontogeny. Fetal liver and adult bone marrow cells were harvest...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35107 | biostudies-arrayexpress
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