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TranscriptomicsHigh-time-resolution dynamic analysis of human regulatory T cell (Treg) / CD4+ T-effector cell (Teff) activation
Human FOXP3+CD25+CD4+ regulatory T cells (Tregs) play a dominant role in the maintenance of immune homeostasis. Several genes are known to be important for murine Tregs, but for human Tregs the genes and underlying molecular networks controlling the suppressor function still largely remain unclear. ...
ORGANISM(S): Homo sapiens 
2012-11-23 | E-GEOD-11292 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human regulatory T cells to identify genes under Foxp3 control
Foxp3, a transcription factor of the forkhead/winged helix family, plays a unique role in the transcriptional control of regulatory CD4+CD25+ T (Treg) cells. The identification of potential target genes associated with the regulatory phenotype and the characterization of combinatorial interactions o...
ORGANISM(S): Homo sapiens 
2005-01-24 | E-MEXP-228 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of macrophages derived from WT and Vdr dificient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3 to study molecular mechanisms of macrophage activation
Gene expression profiling of macrophages derived from WT and Vdr deficient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Foxp3- CD25- regulatory T cells
The concept of immune regulation/suppression has been well-established. With thymus-derived CD4 CD25 regulatory T (TR) cells, it became clear that a variety of additional peripherally induced TR cells play vital roles in protection from many harmful immune responses including intestinal inflammatio...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-12506 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Treg cell versus their controls in human and mouse
We applied Affymetrix GeneChip technology for expression profiling of CD4+CD25+ (Treg) T cells versus their naive CD4+CD25- controls to obtain more information about the underlying molecular mechanisms involved in Treg specific immune suppression Experiment Overall Design: Expression profiles from: ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4571 | biostudies-arrayexpress
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