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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
MetabolomicsRegulation mechanism of gibberellic acid-3 for astaxanthin biosynthesis in heterotrophically growing Chromochloris zofingiensis

Chromochloris zofingiensis has been proved as a potential resource for large-scale astaxanthin production, but little information of phytohormones on growth and astaxanthin accumulation could be obtained. This study explored the impact of gibberellic acid-3 (GA3) on growth and astaxanthin generat...

2024-08-13 | MTBLS10762 | MetaboLights
MetabolomicsThe effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain

This study focuses on deaminotyrosine DAT, a metabolite of gut flora, and systematically investigates its effect on chronic inflammatory pain as well as the underlying mechanism. The research takes high-fat diet HFD as a key entry point for the background, as HFD often leads to an imbalance in th...

2026-08-10 | MTBLS13212 | MetaboLights
MetabolomicsThe effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain

This study focuses on deaminotyrosine DAT, a metabolite of gut flora, and systematically investigates its effect on chronic inflammatory pain as well as the underlying mechanism. The research takes high-fat diet HFD as a key entry point for the background, as HFD often leads to an imbalance in th...

2026-08-10 | MTBLS13221 | MetaboLights
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
MetabolomicsInduction of resistance against Sclerotinia sclerotiorum in rapeseed by β-ocimene through enhanced production of coniferyl aldehyde

Rapeseed (Brassica napus) is an important oil resource, but its yield can be significantly compro-mised by Sclerotinia sclerotiorum (S. sclerotiorum) infection. Due to the lack of rapeseed strains that are highly or completely immune to S. sclerotiorum, enhancing rapeseed resistance through genet...

2025-07-04 | MTBLS12510 | MetaboLights
MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
MetabolomicsWLJP-025p Promote Colonic Epithelial Repair in Ulcerative Colitis through Fatty Acid Oxidation by Regulating Microbial-involvemented SPD Production

BACKGROUND & AIMS: Ulcerative colitis (UC) poses a serious threat to human health. WLJP-025p, a polysaccharide component of Lonicera japonica thunb. has been confirmed to have anti-inflammatory and immunomodulatory effects. This study intends to explore the effects and mechanism of WLJP-025p ...

2026-05-16 | MTBLS12400 | MetaboLights
MetabolomicsMechanism of terpene formation in Pogostemon cablin cv. Jing Huoxiang revealed by metabolome and transcriptome analysis

Pogostemon cablin (Blanco) Benth. cv. 'Jing Huoxiang', is a valuable medicinal plant widely studied for its aboveground tissues, which are rich in bioactive compounds such as patchouli alcohol. However, systematic investigations into the biosynthesis of sesquiterpenes in its underground parts (ro...

2025-10-12 | MTBLS13122 | MetaboLights
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