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Xenografted breast epithelia reveal differences in growth stimulation among contraceptive progestins related to androgenic properties [mouse]
Xenografted breast epithelia reveal differences in growth stimulation among contraceptive progestins related to androgenic properties [human]
Hormonal contraception exposes women to different synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progestins affect the breast epithelium is poorly understood because we lack adequate models to study this. We hypothesized that individual p...
ORGANISM(S): Mus musculus 
2021-05-12 | GSE155273 | GEO
Hormonal contraception exposes women to different synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progestins affect the breast epithelium is poorly understood because we lack adequate models to study this. We hypothesized that individual p...
ORGANISM(S): Homo sapiens 
2021-05-12 | GSE155272 | GEO
Breast cancer cell lines containing the progesterone receptor respond to progestins, altering expression of a subset of genes. In a previously published experiment of inducible knock-down of histone H1 isoforms with an shRNA-expression lentivector (GSE12299), we modified the breast cancer cell line...
ORGANISM(S): Homo sapiens 
C/EBPa mediates the growth inhibitory effect of progestins on breast cancer cells
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