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MetabolomicsDeletion of Gja1 in myocardium emerges ventricular arrhythmia and tachycardia by reprogramming proline metabolism
Connexin43 (Cx43) is the predominant connexin in working myocardium. Its expression decreases in various cardiovascular diseases, and accompanied by ventricular arrhythmias (VAs). However, molecular mechanisms underlying increased arrhythmogenesis remained unclear. Here we established iPSC-derived c...
2025-11-11 | MTBLS13302 | MetaboLights
MetabolomicsMapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC–MS
The metabolism of the parasite Trypanosoma brucei has been the focus of numerous studies since the 1940s. Recently it was shown, using metabolomics coupled with heavy-atom isotope labelled glucose, that the metabolism of the bloodstream form parasite is more complex than previously thought. The pres...
2019-06-24 | MTBLS624 | MetaboLights
ProteomicsYeast homologs of MCUR1 regulate mitochondrial proline metabolism
MCUR1 is an evolutionarily conserved mitochondrial protein that has been shown to act as a scaffold factor for the assembly of the mammalian mitochondrial calcium uniporter (MCU). Surprisingly, many fungi that do not have MCU contain MCUR1 homologs, suggesting these proteins possess alternate functi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-09-30 | PXD015476 | Pride
Proline metabolism Mcur1 Mitochondrion 
MetabolomicsA genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy(Part 1)
Not available
ORGANISM(S): Homo sapiens 
ST002085 | MetabolomicsWorkbench
MetabolomicsA genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy(Part 2)
Not available
ORGANISM(S): Homo sapiens 
ST002084 | MetabolomicsWorkbench
TranscriptomicsAdaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge
Here, we investigated for the first time the systems-wide response of B. subtilis to different simultaneous stresses, i.e. nutrient limitation and high osmolarity. To address the anticipated complexity of the cellular response networks, we combined chemostat experiments under conditions of carbon li...
ORGANISM(S): Bacillus subtilis 
2014-03-31 | E-GEOD-53333 | biostudies-arrayexpress
MetabolomicsNon-targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo
Not available
ORGANISM(S): Canis lupus familiaris 
ST000623 | MetabolomicsWorkbench
TranscriptomicsEssential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae
Rapid adaptation to grow within the physiological conditions found in the host environment is an essential but poorly understood virulence requirement for systemic pathogens such as Streptococcus pneumoniae. We have now demonstrated an essential role for the one-carbon metabolism pathway and a condi...
ORGANISM(S): Streptococcus pneumoniae 
2023-09-10 | E-MTAB-13289 | biostudies-arrayexpress
MetabolomicsFruit setting rewires central metabolism via gibberellin cascades
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on the metabolic behavior in fruit-setting o...
2020-09-11 | MTBLS1892 | MetaboLights
TranscriptomicsImpaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- kno...
ORGANISM(S): Caenorhabditis elegans 
2012-02-25 | E-GEOD-36041 | biostudies-arrayexpress
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