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MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsAmino Acid levels in preB cells under starvation
Not available
ORGANISM(S): Mus musculus 
ST000251 | MetabolomicsWorkbench
MetabolomicsA local source of insulin in the eye governed by phagocytosis and starvation
Not available
ORGANISM(S): Mus musculus 
ST001897 | MetabolomicsWorkbench
MetabolomicsA Phosphate starvation response gene (psr1-like) is present in Micromonas pusilla and other marine algae and coordinates the metabolic response to phosphate deficiency
Both marine phytoplankton and terrestrial plants have to deal with limited bioavailability of the key life nutrient, phosphate. In freshwater algae and plants, a phosphate starvation response gene (psr1) has been characterized, which encodes for a transcription factor that regulates the metabolic re...
2016-02-01 | MTBLS295 | MetaboLights
TranscriptomicsRibosome profiling and RNA sequencing of MCF10A cells treated with torin or by serum starvation
MCF10A were either untreated, treated with torin or by starvation, to induce autophagy. RNA sequencing and ribosome profiling was performed. 1 biological replicate for each condition
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-59816 | biostudies-arrayexpress
UnknownTargeting the Proline-Glutamine-Asparagine-Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy.
Not available
S-EPMC7830038 | biostudies-literature
GenomicsGenome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe [ChIP-Seq data]
Inorganic phosphate is an essential nutrient required by organisms for growth. During phosphate starvation, Saccharomyces cerevisiae activates the phosphate signal transduction (PHO) pathway leading to the expression of the secreted acid phosphatase, PHO5. The fission yeast, Schizosaccharomyces pomb...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2013-01-02 | E-GEOD-39498 | biostudies-arrayexpress
ProteomicsMultilayered regulation of TORC1 signaling by Ait1, Gcn2, and SEAC/GATOR during nitrogen limitation and starvation
The Target of Rapamycin kinase Complex I (TORC1) is a central hub in the cell growth and metabolic control network of eukaryotes. How its upstream regulators cooperate to tune signaling across environmental conditions remains unclear. Here, we combine phosphoproteomics, TORC1 activity assays, and ta...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-11-13 | PXD068726 | Pride
Torc1 Quiescence Seac/gator Nitrogen starvation Gcn2 Ait1 Nutrient sensing Mtor 
TranscriptomicsRestrictions in amino acid availability revealed by differential ribosome codon reading
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-14 | E-GEOD-59821 | biostudies-arrayexpress
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