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TranscriptomicsSch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
The Target Of Rapamycin (TOR) protein is a Ser/Thr kinase that functions in two distinct multiprotein complexes: TORC1 and TORC2. These conserved complexes regulate many different aspects of cell growth in response to intra- and extracellular cues. Here we report the first bona fide substrate of yea...
ORGANISM(S): Saccharomyces cerevisiae 
2010-09-15 | E-GEOD-7660 | biostudies-arrayexpress
ProteomicsMultilayered control of protein turnover by TORC1 and ATG1
To study TORC1-Atg1 signaling comprehensively and to identify potential additional foci of crosstalk, we chose a mass spectrometry (MS)-based phosphoproteomics strategy combing global proteomics screens in vivo with targeted analyses using in vitro kinase reactions. We present the currently largest ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-30 | PXD013271 | Pride
Autophagy Yeast Saccharomyces cerevisiae Phosphorylation Torc1 Phosphoproteomics Rapamycin 
TranscriptomicsTORC1 signaling pathway inhibition by rapamycin and caffeine affect lifespan, global gene expression and cell proliferation of fission yeast
Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model organism to study TOR signaling, although rapamycin has been thought to not affect cell growth in this organism. Here we analyzed the effects of rapamy...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-05 | E-MTAB-1489 | biostudies-arrayexpress
GenomicsTORC1 and PKA dependent gene regulation
TORC1 and PKA dependent gene regulation
PRJNA551977 | ENA
ProteomicsTORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
Target of rapamycin complex 1 (TORC1) promotes biogenesis and inhibits degradation of ribosomes in response to nutrient availability. To ensure a basal supply of ribosomes, cells preserve a small pool of dormant ribosomes under nutrient-limited conditions. The regulation of dormant ribosomes is poor...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-01-19 | PXD037117 | Pride
Protein synthesis Dormant ribosome Proteasome Torc1 Ribosome preservation factor Ribophagy 
ProteomicsMultilayered regulation of TORC1 signaling by Ait1, Gcn2, and SEAC/GATOR during nitrogen limitation and starvation
The Target of Rapamycin kinase Complex I (TORC1) is a central hub in the cell growth and metabolic control network of eukaryotes. How its upstream regulators cooperate to tune signaling across environmental conditions remains unclear. Here, we combine phosphoproteomics, TORC1 activity assays, and ta...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-11-13 | PXD068726 | Pride
Torc1 Quiescence Seac/gator Nitrogen starvation Gcn2 Ait1 Nutrient sensing Mtor 
TranscriptomicsInteraction of Snf1 with TORC1 in yeast Saccharomyces cerevisiae
Snf1 and TORC1 are two global regulators that sense the nutrient availability and regulate the cell growth in yeast Saccharomyces cerevisiae. Here we undertook a systems biology approach to study the effect of deletion of these genes and investigate the interaction between Snf1 and TORC1 in regulati...
ORGANISM(S): Saccharomyces cerevisiae 
2011-10-19 | E-GEOD-24421 | biostudies-arrayexpress
TranscriptomicsSplicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
RNA-seq of C.elegans strain N2 (wt) with and without sfa-1 RNAi at adult day 3 and day 15, C. elegans strain DA1116 (eat-2(ad1116)) with and without sfa-1 RNAi at adult day 3, day 15, and day 27, C. elegans strain SS104 (glp-4(bn2)) with and without hrp-2 RNAi at adult day 1, and HeLa cells with and...
ORGANISM(S): Caenorhabditis elegans 
2016-11-29 | E-MTAB-4866 | biostudies-arrayexpress
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
ProteomicsLeishmania TORC1 links nutrient availability to differentiation into infective
Leishmania TORC1 links nutrient availability to differentiation into infective
ORGANISM(S): Leishmania Mexicana (ncbitaxon:5665) 
2022-10-31 | MSV000090621 | MassIVE
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