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TranscriptomicsThe Estrogen Receptor Co-Regulator Protein, Proline Glutamic Acid and Leucine Rich Protein 1 (PELP1) Mediates Estrogen Rapid Signaling and Neuroprotection in the Brain
We examined the role of PELP1 in E2-ER-mediated transcription in the hippocampus under conditions of GCI by perfroming global transcriptome analysis. E2-treated FLOX and PELP1 FBKO mice were subjected to GCI followed by 24 h reperfusion and the isolated RNA was utilized for RNA-seq analysis. Our res...
ORGANISM(S): Mus musculus 
2015-12-07 | E-GEOD-72136 | biostudies-arrayexpress
ProteomicsStructural Insights into the Role of the Proline Rich Region in Tau Function
Tau is a microtubule-associated protein that plays an important role in modulating axonal microtubules in neurons. Intracellular tau aggregates are found in a broad class of disorders, including Alzheimer’s disease, termed tauopathies. Tau is an intrinsically disordered protein, and its structural d...
ORGANISM(S): Escherichia coli 
2025-01-31 | PXD059518 | Pride
Post-translational modifications Alzheimer's disease Tubulin Tau Phosphorylation Microtubules Aggregation 
UnknownProline-Rich Hypervariable Region of Hepatitis E Virus: Arranging the Disorder.
Not available
S-EPMC7564002 | biostudies-literature
MetabolomicsResearch on the microbiota and metabolic characteristics of type 2 chronic rhinosinusitis based on the analysis of 16S amplicon sequencing combined with metabolomics

Objective:

To investigate the diversity of nasal microbiota and metabolic characteristics of patients with Type 

2 chronic rhinosinusitis, as well as the interactions and potential regulatory relationships between 

the nasal microbiota and their metabolites by conducti...

2025-10-21 | MTBLS13192 | MetaboLights
UnknownMolecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
Not available
S-EPMC5391761 | biostudies-literature
MetabolomicsTranscobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism

BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...

2024-05-28 | MTBLS9136 | MetaboLights
UnknownThe dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region.
Not available
S-EPMC102514 | biostudies-literature
UnknownProline-rich protein from S. mutans can perform a competitive mineralization function to enhance bacterial adhesion to teeth.
Not available
S-EPMC9789152 | biostudies-literature
TranscriptomicsFoxp3 regulates gene expression mostly via its proline-rich interaction region independent of its own DNA-binding domain
Transcriptomic analysis of T helper cells transduced with retroviral expression vectors encoding wild-type and mutant Foxp3.
ORGANISM(S): Mus musculus 
2015-07-02 | E-MTAB-2988 | biostudies-arrayexpress
UnknownThe Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements.
Not available
S-EPMC4850282 | biostudies-literature
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