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Protein hydroxylases are oxygen and alpha-ketoglutarate-dependent enzymes that catalyze hydroxylation of amino acids such as proline, thus linking oxygen and metabolism to enzymatic activity. Prolyl hydroxylation is a dynamic post-translational modification that regulates protein stability and prote...
ORGANISM(S): Homo sapiens (Human) 
2016-05-06 | PXD003621 | Pride
The hydroxylation of proline residues to 4-trans-hydroxyproline (Hyp) is a common post-translational protein modification in plants, mediated by prolyl 4-hydroxylases (P4Hs). Hyps predominantly occur in a group of cell wall proteins, the Hydroxyproline-rich glycoproteins (HRGPs), where they are freq...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) 
2024-08-10 | PXD051497 | Pride
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an /-heterodimeric transcription factor that regulates the expression of hundreds of genes in a context dependent manner. A hypoxia-sensing component of the HIF system involves oxygen-dependent ca...
ORGANISM(S): Homo sapiens 
Collagen from the skin of wild type and prolyl 4-hydroxylase mutant mice was extracted and proline hydroxylation of the collagen-derived peptides were analyzed by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2018-04-10 | PXD008802 | Pride
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