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ProteomicsReprograming of Proteasomal Degradation by Branched Chain Amino Acid Metabolism
Branched chain amino acids (BCAAs) play an important role in energy and protein regulation. Defects in BCAA metabolism are linked to numerous pathologies, including diabetes, neurodegeneration, and premature aging. Isovaleric acidemia is a metabolic disease caused by defective leucine breakdown and ...
ORGANISM(S): Caenorhabditis elegans 
2022-09-22 | PXD028286 | Pride
C. elegans  ubiquitin  leucine catabolism  branched chain amino acid (bcaa)  bcat  ivd  isovaleric acidemia 
ProteomicsDeciphering the involvement of the Hippo pathway co - regulators, YAP/TAZ in invadopodia formation and matrix degradation
Invadopodia are adhesive, actin - rich pro trusions , formed by metastatic cancer cells , that degrade the extracellular matrix and facilitate invasion . They support the metastatic cascade by a spatially and temporally coordinated process where by invading cells bind to the matrix , degrade it by s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD034562 | Pride
Prote omic profiling Tks5 Extracellular matrix Yap Hippo pathway I nvadopodia Actin Taz Gelatin degradation Cancer metastasis Mmp14 (mt1 - mmp) Rna sequencing 
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