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ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Mus Musculus (ncbitaxon:10090) 
MSV000086102 | MassIVE
ProteomicsIntegrated transcriptomic and proteomic analyses revealed the participation of endogenous protease inhibitors in the regulation of protease gene expression in Helicoverpa armigera
Insects adapt to plant protease inhibitors (PIs) present in their diet by differentially regulating multiple digestive proteases. However, mechanisms regulating protease gene expression in insects are largely enigmatic. Ingestion of Capsicum annuum protease inhibitor-7 (CanPI-7) arrests growth and d...
ORGANISM(S): Helicoverpa armigera (Cotton bollworm) 
2018-04-25 | PXD008376 | Pride
Transcriptome Protease regulation Swath Tripletof 5600 Insect adaptation Helicoverpa armigera Plant protease inhibitor 
TranscriptomicsGene expression profiling of rat jejunum treated with MLT-943, a small molecule MALT1 protease inhibitor
MALT1 protease inhibition is effective in several preclinical models of autoimmunity and B cell malignancies. However, severe reduction in regulatory T cells (Tregs) and an associated IPEX-like pathology was observed in mice with congenital deficiency of MALT1. Rats treated with MLT-943, a novel pot...
ORGANISM(S): Rattus norvegicus 
2020-04-30 | E-MTAB-8990 | biostudies-arrayexpress
OtherNative Metabolomics Protease Inhibitor Screening of Cyanobacteria Extracts
Native metabolomics of environmental cyanobacteria extracts and purified fractions for screening of protease inhibitors
ORGANISM(S): Rivularia (ncbitaxon:373984) 
2021-08-10 | MSV000087964 | MassIVE
ProteomicsD. magna CT448 protease specificity
Mass developments of toxin-producing cyanobacteria are frequently observed in freshwater ecosystems due to eutrophication and global warming. These mass developments can partly be attributed to cyanobacterial toxins, such as protease inhibitors (PIs), which inhibit digestive serine proteases of Daph...
ORGANISM(S): Daphnia magna 
2018-10-04 | PXD010978 | Pride
Ct448 pics protease specificity 
ProteomicsDesign and synthesis of tailored human caseinolytic protease P inhibitors
Human caseinolytic protease P (hClpP) is important for degradation of misfolded proteins in the mitochondrial unfolded protein response. We here introduce tailored hClpP inhibitors that utilize a steric discrimination in their core naphthofuran scaffold to selectively address the human enzyme. This ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD010277 | Pride
Mitochondria Jurkat Clpp Huh7 Phenyl esters 
ProteomicsProteases in Quercus ilex seeds
Proteases and protease inhibitors have been analyzed in the non-orthodox Quercus ilex forest tree by using in silico and wet approaches. The in silico analysis showed that the species-specific transcriptome database included 2240 and 97 transcripts annotated as, respectively, proteases and protease ...
ORGANISM(S): Quercus ilex (Holly oak) 
2022-08-11 | PXD032845 | Pride
Proteomics Protease inhibitors Protease Germination Quercus ilex Non-orthodox seed Protease activity 
TranscriptomicsTranscription profiling of testis from Sertoli cell-selective androgen receptor knockout mice and wild type mice to unravel the molecular mechanisms mediating the effects of androgens on spermatogenesis
To unravel the molecular mechanisms mediating the effects of androgens on spermatogenesis, testicular gene expression was compared in mice with a Sertoli cell-selective androgen receptor knockout (SCARKO) and littermate controls on postnatal d 10. At this age testicular cell composition is still com...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2260 | biostudies-arrayexpress
ProteomicsEffect of Kinase Inhibitors on Intraerythrocytic Plasmodium falciparum Phosphoproteome
Three flasks of asynchronous blood stage P. falciparum Dd2 culture were grown to ~15% parasitemia, 4% hematocrit using the Trager- Jensen method. Per biological replicate, parasites were treated with 5 x EC50 or EC90 of compound depending on the slope of the EC50 curve for 3 hours. Compounds are DC-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Plasmodium Falciparum Dd2 (ncbitaxon:57267) 
2023-04-03 | MSV000091619 | MassIVE
TranscriptomicsEssential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse larg...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-41034 | biostudies-arrayexpress
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