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MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
ProteomicsIdentification of a precursor processing protease from the spider Cupiennius salei essential for venom neurotoxin maturation
Spider venom neurotoxins and cytolytic peptides are expressed as elongated precursor peptides, which are post-translationally processed by proteases to yield the active mature peptides. The recognition motifs for these processing proteases, first published more than ten years ago, include the Proces...
ORGANISM(S): Cupiennius salei (American wandering spider) 
2018-01-02 | PXD007126 | Pride
Ipqm Neurotoxin Pqm Propeptide Venom Cupiennius salei Processing quadruplet motif Protease Enzyme purification 
GenomicsHP1BP3, a chromatin retention factor for co-transcriptional microRNA processing (ChIP-Seq)
Identification and characterization of HP1BP3 (a human histone H1 homologue) as a novel chromatin retention factor essential for the co-transcriptional processing of pri-miRNA. We generated BAC transgenic cells at 80% confluency (~1x107) were cross-linked with 1% formaldehyde for 10 minutes at 37°C...
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77854 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
ProteomicsMPP profiling in yeast - Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals a set of non-substrate proteins increased upon proteotoxic stress
The majority of mitochondrial preproteins is targeted via N-terminal presequences that are cleaved upon import into the organelle. The essential mitochondrial processing protease (MPP) is assumed to cleave the majority of incoming precursors. However, only few substrate proteins of MPP have been exp...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-10-14 | PXD002063 | Pride
Mitochondrial processing protease mpp Mitochondria Chafradic Mitochondrial stress response Presequence import pathway 
GenomicsProtease-mediated processing of Argonaute proteins controls small RNA association [smallRNA-Seq]
Protease-mediated processing of Argonaute proteins controls small RNA association [smallRNA-Seq]
PRJNA637042 | ENA
GenomicsProtease-mediated processing of Argonaute proteins controls small RNA association [RNA-Seq]
Protease-mediated processing of Argonaute proteins controls small RNA association [RNA-Seq]
PRJNA637040 | ENA
TranscriptomicsGene expression profiling of rat jejunum treated with MLT-943, a small molecule MALT1 protease inhibitor
MALT1 protease inhibition is effective in several preclinical models of autoimmunity and B cell malignancies. However, severe reduction in regulatory T cells (Tregs) and an associated IPEX-like pathology was observed in mice with congenital deficiency of MALT1. Rats treated with MLT-943, a novel pot...
ORGANISM(S): Rattus norvegicus 
2020-04-30 | E-MTAB-8990 | biostudies-arrayexpress
GenomicsProtease-mediated processing of Argonaute proteins controls small RNA association [RIP-Seq]
Protease-mediated processing of Argonaute proteins controls small RNA association [RIP-Seq]
PRJNA637041 | ENA
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