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MetabolomicsMetabolite control of enzyme activity links stress to biosynthetic regulation

Cells must continuously adjust metabolic output to maintain homeostasis under changing environmental conditions, yet the mechanisms that enable rapid and reversible control of pathway activity remain largely unknown. The methylerythritol phosphate (MEP) pathway, of bacterial origin and conserved ...

2026-02-04 | MTBLS12456 | MetaboLights
ProteomicsIntegrated transcriptomic and proteomic analyses revealed the participation of endogenous protease inhibitors in the regulation of protease gene expression in Helicoverpa armigera
Insects adapt to plant protease inhibitors (PIs) present in their diet by differentially regulating multiple digestive proteases. However, mechanisms regulating protease gene expression in insects are largely enigmatic. Ingestion of Capsicum annuum protease inhibitor-7 (CanPI-7) arrests growth and d...
ORGANISM(S): Helicoverpa armigera (Cotton bollworm) 
2018-04-25 | PXD008376 | Pride
Transcriptome Protease regulation Swath Tripletof 5600 Insect adaptation Helicoverpa armigera Plant protease inhibitor 
TranscriptomicsM-OM-^CB-dependent yabJ-spoVG operon involved in regulation of extracellular nuclease, lipase and protease expression in Staphylococcus aureus
The alternative sigma factor M-OM-^CB of Staphylococcus aureus is involved in the coordination of the general stress response, expression of virulence determinants and modulation of antibiotic resistance levels. It controls a large regulon, either directly by recognizing conserved M-OM-^CB promoter ...
ORGANISM(S): Staphylococcus aureus 
2011-11-23 | E-GEOD-30115 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of rat jejunum treated with MLT-943, a small molecule MALT1 protease inhibitor
MALT1 protease inhibition is effective in several preclinical models of autoimmunity and B cell malignancies. However, severe reduction in regulatory T cells (Tregs) and an associated IPEX-like pathology was observed in mice with congenital deficiency of MALT1. Rats treated with MLT-943, a novel pot...
ORGANISM(S): Rattus norvegicus 
2020-04-30 | E-MTAB-8990 | biostudies-arrayexpress
TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
ProteomicsSelective regulation of aspartyl intramembrane protease activity by calnexin
Signal peptide peptidase-like 2c (SPPL2c) is a testis-specific aspartyl intramembrane protease that contributes to male gamete function both by catalytic and non-proteolytic mechanisms. Here, we provide an unbiased characterisation of the in vivo interactome of SPPL2c identifying the ER chaperone ca...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052965 | Pride
Co-ip Signal peptide peptidase-like 2c Mouse Calnexin Sppl2c Testis 
TranscriptomicsA lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Expression data from CD34+ hematopoietic cells transduced with control or anti-SLPI shRNA, serum starved and treated with G-CSF. CD34+ hematopoietic cells were isolated from the bone marrow of healthy individuals, transduced with lenitvirus-based RFP-expressed shRNA constructs targeting SLPI mRNA or...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-53353 | biostudies-arrayexpress
ProteomicsPrkA regulates Bacillus subtilis sporulation through a Lon protease activity
In Bacillus subtilis, sporulation is a sequential and highly regulated process. Phosphorylation events by Histidine or Serine/Threonine kinases are key points in this regulation. PrkA has been proposed to be an essential Serine kinase for the initiation of sporulation but its kinase activity has not...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2022-10-15 | PXD032931 | Pride
Atpase Prka Lon protease Sporulation Phosphorylation Bacillus subtilis 
ProteomicsIdentification of potential mitochondrial CLPXP protease interactors and substrates
Maintenance of mitochondria is achieved by several mechanisms, including the regulation of mitochondrial proteostasis. The matrix protease CLPXP, involved in protein quality control, has been implicated in ageing and disease. However, particularly due to the lack of knowledge of CLPXP’s substrate sp...
ORGANISM(S): Podospora 
2016-07-27 | PXD003264 | Pride
Mitochondria Aging Clpxp protease 
GenomicsIdentifying the regulon of the Sinorhizobium meliloti JspA protease
Identifying the regulon of the Sinorhizobium meliloti JspA protease
PRJNA655728 | ENA
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