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ProteomicsElucidation of the signatures of proteasome-catalysed peptide splicing
Proteasomes catalyse the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalysed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD021339 | Pride
Protein splicing Proteasome Splicing mechanism 
ProteomicsElucidation of the Signatures of Proteasome-Catalyzed Peptide Splicing
Proteasomes catalyze the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalyzed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2021-05-17 | PXD025893 | Pride
Peptide spliicng Proteasome Antigen processing 
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-13 | MSV000086452 | MassIVE
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD010793 | Pride
Lc-msms Immunopeptidomics Proteasomal splicing Hla-i peptides 
UnknownDefinition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules.
Not available
S-EPMC4642839 | biostudies-literature
ProteomicsPost-translational regulation of the exon skipping machinery controls aberrant splicing in T cell leukemia
Splicing alterations are very common in cancer and might affect disease initiation and progression. In several cancers, mutations in splicing factor genes are responsible for aberrant splicing. We show that certain aggressive cancers, such as pediatric T-cell acute lymphoblastic leukemia (T-ALL), ha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084383 | MassIVE
UnknownChronic arsenic exposure suppresses proteasomal and autophagic protein degradation.
Not available
S-EPMC11465505 | biostudies-literature
UnknownPosttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.
Not available
S-EPMC7483384 | biostudies-literature
UnknownElucidation of the Signatures of Proteasome-Catalyzed Peptide Splicing.
Not available
S-EPMC7541919 | biostudies-literature
UnknownTSGΔ154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation.
Not available
S-EPMC4884989 | biostudies-literature
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