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GenomicsEffects of an autophagy-related protein degrader on murine 4T1 breast cancer model
Effects of an autophagy-related protein degrader on murine 4T1 breast cancer model
PRJNA1473653 | ENA
UnknownMechanism of degrader-targeted protein ubiquitinability.
Not available
S-EPMC11468923 | biostudies-literature
ProteomicsMechanism of degrader-targeted protein ubiquitinability
Small molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and the potential to tackle previously undrugged targets. Thermodynamically stable and kinetically long-lived degrader-mediated ternary complexes can drive faster, more profound...
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD053502 | Pride
Mz1 Vhl Ubiquitination 
Genomicspan-Kinase degrader response time course
pan-Kinase degrader response time course
PRJNA661753 | ENA
TranscriptomicsEffects of an autophagy-related protein degrader on murine 4T1 breast cancer model
We developed an targeted protein degrader that could degrade VPS34, a key factor for autophagy initiation, to inhibit autophagy pathway in tumor. We did bulk RNA-seq to investigate how such protein degrader modulated the gene expression regarding autophagy pathway and immune response.
ORGANISM(S): Mus musculus 
2026-06-06 | GSE334050 | GEO
GenomicsDiscovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies
Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies
PRJNA1284952 | ENA
ProteomicsMapping the Degradable Kinome: A Resource for Expedited Degrader Development
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD021242 | Pride
Ubiquitin E3 ligase. Ubiquitin proteasome system Protac Imid Degrader Targeted degradation Kinase 
ProteomicsMapping the Degradable Kinome: A Resource for Expedited Degrader Development
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD021255 | Pride
Ubiquitin Ubiquitin proteasome system Protac Imid Degrader Targeted degradation E3 ligase Kinase 
ProteomicsMapping the Degradable Kinome: A Resource for Expedited Degrader Development
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD021313 | Pride
Ubiquitin E3 ligase. Ubiquitin proteasome system Protac Imid Degrader Targeted degradation Kinase 
ProteomicsMapping the Degradable Kinome: A Resource for Expedited Degrader Development
Targeted protein degradation refers to the use of small molecule inducers of ubiquitin-dependent degradation of proteins and enables the development of drugs to previously inaccessible targets. Degrader development is an empirical process due to a poor understanding of the key properties that requi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD021240 | Pride
Ubiquitin E3 ligase. Ubiquitin proteasome system Protac Imid Degrader Targeted degradation Kinase 
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